caa a22 4500 475774620 CHVBK 20180406123627.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1007/s004180000142 doi (NATIONALLICENCE)springer-10.1007/s004180000142 Expression of the janus kinases - signal transducers and activators of transcription pathway in Hassall's corpuscles of the human thymus [Elektronische Daten] [Hajime Nishio, Kiyoshi Matsui, Hiroko Tsuji, Akiyoshi Tamura, Koichi Suzuki] Abstract.: The janus kinases (JAK) and signal transducers and activators of transcription (STAT) pathway has been shown to play a key role in cytokine-mediated signal transduction, and to regulate growth, differentiation, and death of both normal and transformed cells. In the present study, we investigated immunohistochemically the distribution of the JAK-STAT pathway in the human thymus. Various elements of the pathway were abundantly expressed in Hassall's corpuscles, located in the thymus medulla and representing terminal stages of the thymic medullary epithelium. Furthermore, the elements of the pathway showed distinct localization in Hassall's corpuscles. JAK1, JAK2, and TYK2 were expressed in high amounts in the entirety of Hassall's corpuscles, whereas JAK3 was in the outer layer. STAT1, STAT2, and STAT6 were abundantly expressed in the entire Hassall's corpuscles, whereas STAT5 was in the outer layer. These findings strongly suggest that the JAK-STAT pathway may play a role in thymic medullary epithelial maturation. Springer-Verlag, 2000 JAK STAT Hassall's corpuscles Tyrosine phosphorylation Immunohistochemistry nationallicence Nishio Hajime Department of Legal Medicine, Osaka Medical College, 2-7 Daigaku, Takatsuki, 569-8686, Japan aut Matsui Kiyoshi Department of Legal Medicine, Osaka Medical College, 2-7 Daigaku, Takatsuki, 569-8686, Japan aut Tsuji Hiroko Department of Legal Medicine, Osaka Medical College, 2-7 Daigaku, Takatsuki, 569-8686, Japan aut Tamura Akiyoshi Department of Legal Medicine, Osaka Medical College, 2-7 Daigaku, Takatsuki, 569-8686, Japan aut Suzuki Koichi Department of Legal Medicine, Osaka Medical College, 2-7 Daigaku, Takatsuki, 569-8686, Japan aut https://doi.org/10.1007/s004180000142 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004180000142 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nishio Hajime Department of Legal Medicine, Osaka Medical College, 2-7 Daigaku, Takatsuki, 569-8686, Japan aut NATIONALLICENCE 700 1- Matsui Kiyoshi Department of Legal Medicine, Osaka Medical College, 2-7 Daigaku, Takatsuki, 569-8686, Japan aut NATIONALLICENCE 700 1- Tsuji Hiroko Department of Legal Medicine, Osaka Medical College, 2-7 Daigaku, Takatsuki, 569-8686, Japan aut NATIONALLICENCE 700 1- Tamura Akiyoshi Department of Legal Medicine, Osaka Medical College, 2-7 Daigaku, Takatsuki, 569-8686, Japan aut NATIONALLICENCE 700 1- Suzuki Koichi Department of Legal Medicine, Osaka Medical College, 2-7 Daigaku, Takatsuki, 569-8686, Japan aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer