caa a22 4500 475774671 CHVBK 20180406123627.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s004180050444 doi (NATIONALLICENCE)springer-10.1007/s004180050444 Immunohistochemical distribution of galectin-1, galectin-3, and olfactory marker protein in human olfactory epithelium [Elektronische Daten] [S. Heilmann, T. Hummel, F. L. Margolis, M. Kasper, M. Witt] Abstract : The expression pattern of galectin-1 and galectin-3 in the human olfactory epithelium was investigated in relation to olfactory marker protein (OMP) using confocal laser immunofluorescence in human specimens and postmortem biopsies. OMP expression was found in olfactory receptor neurons (ORNs) in the olfactory mucosa and in fibers of the olfactory nerve crossing the submucous connective tissue. Galectin-1 was expressed in both the connective tissue of the nasal cavity and in the basal layer of the olfactory epithelium. In contrast, galectin-3 expression was limited to cells of the upper one-third of the olfactory epithelium. Expression of galectin-3 occurred in a subset of OMP-positive cells. However, between areas of galectin-1 and galectin-3 expression in the lower and upper portion of the epithelium, OMP-positive ORNs did not stain for both galectins. Considering the potential role of galectin-1 and galectin-3 in cell differentiation and maturation, the differential localization of galectins in the olfactory epithelium appears to be consistent with a significant role of these molecules in the physiological turnover of ORNs. Springer-Verlag Berlin Heidelberg, 2000 Heilmann S. Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, 01307 Dresden, Germany e-mail: thummel@rcs.urz.tu-dresden.de Tel.: +49-351-4584189, Fax: +49-351-4584326, DE aut Hummel T. Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, 01307 Dresden, Germany e-mail: thummel@rcs.urz.tu-dresden.de Tel.: +49-351-4584189, Fax: +49-351-4584326, DE aut Margolis F. L. Department of Anatomy and Neurobiology, University of Maryland at Baltimore School of Medicine, 685 West Baltimore Street, Baltimore MD 21201, USA, US aut Kasper M. Department of Anatomy, University of Dresden Medical School, Fetscherstrasse 74, 01307 Dresden, Germany, DE aut Witt M. Department of Anatomy, University of Dresden Medical School, Fetscherstrasse 74, 01307 Dresden, Germany, DE aut https://doi.org/10.1007/s004180050444 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004180050444 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Heilmann S. Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, 01307 Dresden, Germany e-mail: thummel@rcs.urz.tu-dresden.de Tel.: +49-351-4584189, Fax: +49-351-4584326, DE aut NATIONALLICENCE 700 1- Hummel T. Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, 01307 Dresden, Germany e-mail: thummel@rcs.urz.tu-dresden.de Tel.: +49-351-4584189, Fax: +49-351-4584326, DE aut NATIONALLICENCE 700 1- Margolis F. L. Department of Anatomy and Neurobiology, University of Maryland at Baltimore School of Medicine, 685 West Baltimore Street, Baltimore MD 21201, USA, US aut NATIONALLICENCE 700 1- Kasper M. Department of Anatomy, University of Dresden Medical School, Fetscherstrasse 74, 01307 Dresden, Germany, DE aut NATIONALLICENCE 700 1- Witt M. Department of Anatomy, University of Dresden Medical School, Fetscherstrasse 74, 01307 Dresden, Germany, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer