caa a22 4500 475774760 CHVBK 20180406123628.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s004180050435 doi (NATIONALLICENCE)springer-10.1007/s004180050435 Improved quantitative characterization of atherosclerotic plaque composition with immunohistochemistry, confocal fluorescence microscopy, and computer-assisted image analysis [Elektronische Daten] [D. J. Taatjes, M. P. Wadsworth, D. J. Schneider, B. E. Sobel] Abstract : To quantitatively characterize contributions of major constituents to the composition of a given atherosclerotic plaque, we have developed an approach employing immunohistochemistry, confocal scanning laser microscopy, and computer-assisted image analysis. The method developed permits identification of plaques that are particularly vulnerable to rupture and elucidation of the nature of the composition of a given plaque, as well as the extent of luminal encroachment. Thus, it should be useful in experimental animals and ultimately in patients in delineating compositional changes in response to potentially deleterious genetic and environmentally induced factors and to potentially therapeutic interventions designed to diminish plaque vulnerability. Springer-Verlag Berlin Heidelberg, 2000 Taatjes D. J. Department of Pathology, College of Medicine, Medical Alumni Building, University of Vermont, Burlington, VT 05405, USA e-mail: dtaatjes@salus.uvm.edu Tel.: +1-802-6560373, Fax: +1-802-6568892, US aut Wadsworth M. P. Department of Pathology, College of Medicine, Medical Alumni Building, University of Vermont, Burlington, VT 05405, USA e-mail: dtaatjes@salus.uvm.edu Tel.: +1-802-6560373, Fax: +1-802-6568892, US aut Schneider D. J. Department of Medicine, College of Medicine, University of Vermont, Burlington, VT 05405, USA, US aut Sobel B. E. Department of Medicine, College of Medicine, University of Vermont, Burlington, VT 05405, USA, US aut https://doi.org/10.1007/s004180050435 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004180050435 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Taatjes D. J. Department of Pathology, College of Medicine, Medical Alumni Building, University of Vermont, Burlington, VT 05405, USA e-mail: dtaatjes@salus.uvm.edu Tel.: +1-802-6560373, Fax: +1-802-6568892, US aut NATIONALLICENCE 700 1- Wadsworth M. P. Department of Pathology, College of Medicine, Medical Alumni Building, University of Vermont, Burlington, VT 05405, USA e-mail: dtaatjes@salus.uvm.edu Tel.: +1-802-6560373, Fax: +1-802-6568892, US aut NATIONALLICENCE 700 1- Schneider D. J. Department of Medicine, College of Medicine, University of Vermont, Burlington, VT 05405, USA, US aut NATIONALLICENCE 700 1- Sobel B. E. Department of Medicine, College of Medicine, University of Vermont, Burlington, VT 05405, USA, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer