caa a22 4500 475774949 CHVBK 20180406123628.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s004180000154 doi (NATIONALLICENCE)springer-10.1007/s004180000154 Ultrastructural study of relationships between c-kit immunoreactive interstitial cells and other cellular elements in the human colon [Elektronische Daten] [Christophe Mazzia, Christophe Porcher, Yvon Julé, Marie-Odile Christen, Monique Henry] Abstract.: C-kit immunocytochemistry was performed on ultrathin sections of human distal colon. Our attention was focused on relationships between c-kit immunoreactive interstitial cells (c-kitICs) and muscular cells and nervous elements located in the external muscular layers of the colonic wall. C-kitICs established membrane apposition with both nerve fibers and smooth muscle cells of, respectively, the longitudinal and circular muscle layers, the myenteric area, and the extremus submucosus plexus. C-kitICs also surrounded the external submucosus plexus and established membrane appositions with nerve elements located inside the myenteric ganglia. These membrane appositions were observed either at the level of the c-kitIC bodies or at that of their cytoplasmic processes. In some cases, membrane appositions were observed concomitantly between the c-kitICs, nerve fibers, and smooth muscle cells. In all the regions studied, the c-kitICs were also found to be located in the close vicinity of blood vessels and to have established close contacts with non-immunoreactive fibroblast-like cells. The results of the present study shed essential light on the relationships of c-kitICs with the neighboring muscle cells and nerve elements, and confirm that the intercalated c-kitICs well fit with the so-called "interstitial cells of Cajal". Springer-Verlag, 2000 C-kit Interstitial cells Ultrastructure Man Colon nationallicence Mazzia Christophe Département de Physiologie et Neurophysiologie, Laboratoire de Neurobiologie des Fonctions Végétatives, CNRS-ESA 6034, Faculté des Sciences Marseille Saint-Jérôme, 13397 Marseille cedex 20, France aut Porcher Christophe Département de Physiologie et Neurophysiologie, Laboratoire de Neurobiologie des Fonctions Végétatives, CNRS-ESA 6034, Faculté des Sciences Marseille Saint-Jérôme, 13397 Marseille cedex 20, France aut Julé Yvon Département de Physiologie et Neurophysiologie, Laboratoire de Neurobiologie des Fonctions Végétatives, CNRS-ESA 6034, Faculté des Sciences Marseille Saint-Jérôme, 13397 Marseille cedex 20, France aut Christen Marie-Odile Laboratoires Solvay-Pharma, 42, rue Rouget de Lisle, 92151 Suresnes, France aut Henry Monique Département de Physiologie et Neurophysiologie, Laboratoire de Neurobiologie des Fonctions Végétatives, CNRS-ESA 6034, Faculté des Sciences Marseille Saint-Jérôme, 13397 Marseille cedex 20, France aut https://doi.org/10.1007/s004180000154 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004180000154 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mazzia Christophe Département de Physiologie et Neurophysiologie, Laboratoire de Neurobiologie des Fonctions Végétatives, CNRS-ESA 6034, Faculté des Sciences Marseille Saint-Jérôme, 13397 Marseille cedex 20, France aut NATIONALLICENCE 700 1- Porcher Christophe Département de Physiologie et Neurophysiologie, Laboratoire de Neurobiologie des Fonctions Végétatives, CNRS-ESA 6034, Faculté des Sciences Marseille Saint-Jérôme, 13397 Marseille cedex 20, France aut NATIONALLICENCE 700 1- Julé Yvon Département de Physiologie et Neurophysiologie, Laboratoire de Neurobiologie des Fonctions Végétatives, CNRS-ESA 6034, Faculté des Sciences Marseille Saint-Jérôme, 13397 Marseille cedex 20, France aut NATIONALLICENCE 700 1- Christen Marie-Odile Laboratoires Solvay-Pharma, 42, rue Rouget de Lisle, 92151 Suresnes, France aut NATIONALLICENCE 700 1- Henry Monique Département de Physiologie et Neurophysiologie, Laboratoire de Neurobiologie des Fonctions Végétatives, CNRS-ESA 6034, Faculté des Sciences Marseille Saint-Jérôme, 13397 Marseille cedex 20, France aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer