caa a22 4500 475775309 CHVBK 20180406123629.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1023/A:1007178924408 doi (NATIONALLICENCE)springer-10.1023/A:1007178924408 Use of caryophyllene oxide as an antifungal agent in an in vitro experimental model of onychomycosis [Elektronische Daten] [Depo Yang, Laura Michel, Jean-Pierre Chaumont, Joëlle Millet-Clerc] Caryophyllene oxide, an oxygenated terpenoid, well known as preservative in food, drugs and cosmetics, has been tested in vitro as an antifungal against dermatophytes. Its antifungal activity has been compared to ciclopiroxolamine and sulconazole, commonly used in onychomycosis treatment and chosen because of their very different chemical structures. So, a new model has been tested, utilizing sheep hoof plates in order to simulate human nails, which are almost unobtainable for in vitro tests. Three protocols were utilized: pre-treatment. simultaneous treatment and post-treatment. Among these, the post-treatment method was the best to simulate antifungal therapy. as it permitted testing and comparing the efficiency of different antifungal drugs. Kluwer Academic Publishers, 1999 Antifungal nationallicence caryophyllene oxide nationallicence onychomycosis model nationallicence sheep hoof plate nationallicence Yang Depo Laboratoire de Pharmacic Galénique, Faculté de Médecine et de Pharmacie, Place Saint-Jacques, 25030, Besançon Cedex, France aut Michel Laura Laboratoire de Pharmacic Galénique, Faculté de Médecine et de Pharmacie, Place Saint-Jacques, 25030, Besançon Cedex, France aut Chaumont Jean-Pierre Laboratoire de Botanique et Cryptogamie, Faculté de Médecine et de Pharmacie, Place Saint-Jacques, 25030, Besançon Cedex, France aut Millet-Clerc Joëlle Laboratoire de Pharmacic Galénique, Faculté de Médecine et de Pharmacie, Place Saint-Jacques, 25030, Besançon Cedex, France aut Mycopathologia Kluwer Academic Publishers 148/2(2000-03-01), 79-82 0301-486X 148:2<79 2000 148 11046 https://doi.org/10.1023/A:1007178924408 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1007178924408 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yang Depo Laboratoire de Pharmacic Galénique, Faculté de Médecine et de Pharmacie, Place Saint-Jacques, 25030, Besançon Cedex, France aut NATIONALLICENCE 700 1- Michel Laura Laboratoire de Pharmacic Galénique, Faculté de Médecine et de Pharmacie, Place Saint-Jacques, 25030, Besançon Cedex, France aut NATIONALLICENCE 700 1- Chaumont Jean-Pierre Laboratoire de Botanique et Cryptogamie, Faculté de Médecine et de Pharmacie, Place Saint-Jacques, 25030, Besançon Cedex, France aut NATIONALLICENCE 700 1- Millet-Clerc Joëlle Laboratoire de Pharmacic Galénique, Faculté de Médecine et de Pharmacie, Place Saint-Jacques, 25030, Besançon Cedex, France aut NATIONALLICENCE 773 0- Mycopathologia Kluwer Academic Publishers 148/2(2000-03-01), 79-82 0301-486X 148:2<79 2000 148 11046 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer