caa a22 4500 475778839 CHVBK 20180406123638.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1007/s004640000098 doi (NATIONALLICENCE)springer-10.1007/s004640000098 The influence of different insufflation pressures during carbon dioxide pneumoperitoneum on the development of pulmonary metastasis in a mouse model [Elektronische Daten] [H. Ishida, N. Murata, M. Yokoyama, N. Ishizuka, I. Takeuchi, A. Odaka, K. Shimomura, M. Fujioka, Y. Idezuki] Background: The effects of different insufflation pressures on the development of pulmonary metastasis was investigated in a mouse laparoscopy model. Methods: BALB/C mice intravenously inoculated with colon 26 cells were randomized to one of five treatment groups (10 mice per group): pneumoperitoneum at different pressures of 5, 10 or 15 mmHg; full laparotomy for 60 min; or anesthesia control. Cancer nodules on the lung surface 19 days postoperatively were compared between groups. Results: (a) As compared with the control group, pneumoperitoneum at 10 and 15 mmHg and laparotomy enhanced the growth of pulmonary metastases (p < 0.01). (b) The growth of metastases also was greater in laparotomy group mice than in mice undergoing pneumoperitoneum at 5 and 10 mmHg (p < 0.05). Conclusions: These results suggest that the effects of different insufflation pressures on the growth of pulmonary metastases are not identical, and that pneumoperitoneum with high pressure may promote pulmonary metastases similar to those with laparotomy. Springer-Verlag New York Inc., 2000 Key words: Colon 26 — Colorectal cancer — Laparoscopic surgery — Pneumoperitoneum — Pulmonary metastasis nationallicence Ishida H. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, JP aut Murata N. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, JP aut Yokoyama M. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, JP aut Ishizuka N. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, JP aut Takeuchi I. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, JP aut Odaka A. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, JP aut Shimomura K. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, JP aut Fujioka M. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, JP aut Idezuki Y. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, JP aut Surgical Endoscopy Springer-Verlag 14/6(2000-06-01), 578-581 0930-2794 14:6<578 2000 14 464 https://doi.org/10.1007/s004640000098 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004640000098 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ishida H. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, JP aut NATIONALLICENCE 700 1- Murata N. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, JP aut NATIONALLICENCE 700 1- Yokoyama M. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, JP aut NATIONALLICENCE 700 1- Ishizuka N. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, JP aut NATIONALLICENCE 700 1- Takeuchi I. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, JP aut NATIONALLICENCE 700 1- Odaka A. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, JP aut NATIONALLICENCE 700 1- Shimomura K. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, JP aut NATIONALLICENCE 700 1- Fujioka M. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, JP aut NATIONALLICENCE 700 1- Idezuki Y. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, JP aut NATIONALLICENCE 773 0- Surgical Endoscopy Springer-Verlag 14/6(2000-06-01), 578-581 0930-2794 14:6<578 2000 14 464 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer