caa a22 4500 475779266 CHVBK 20180406123639.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/s004640000213 doi (NATIONALLICENCE)springer-10.1007/s004640000213 Coagulation activation after laparoscopic cholecystectomy in spite of thromboembolism prophylaxis [Elektronische Daten] [F. Lindberg, I. Rasmussen, A. Siegbahn, D. Bergqvist] Background: The aim of this study was to determine whether laparoscopic cholecystectomy (LC), in spite of its minimally invasive nature, causes coagulation activation. Methods: Sixty-four patients undergoing LC were included prospectively. All received either dextran or low-molecular-weight heparin (LMWH). Blood samples taken the morning of the operation and the following morning were analyzed for TAT, FM, fragment 1+2, tPA, PAI-1, vWf, D-dimer, Hb, hematocrit, and APC resistance. Results: Significant increases in TAT, FM, fragment 1+2, and D-dimer were seen, whereas APC resistance, Hb, and hematocrit decreased significantly. Dextran led to a decrease in vWf and no change in tPA, whereas LMWH led to an increase in both these parameters. Conclusions: Laparoscopic cholecystectomy causes coagulation activation. There are differences in the response between patients receiving dextran and LMWH as thromboembolism prophylaxis. Since most patients are discharged the day after the operation, there could be practical as well as theoretical advantages to using dextran. Springer-Verlag New York Inc., 2000 Key words: Laparoscopic cholecystectomy — Coagulation activation — Thromboembolism prophylaxis — Dextran — Low-molecular-weight heparin — Gallbladder nationallicence Lindberg F. Department of Surgery, Skellefteå County Hospital, SE-931 86 Skellefteå, Sweden, Sweden aut Rasmussen I. Department of Surgery, University Hospital, SE-751 85 Uppsala, Sweden, Sweden aut Siegbahn A. Department of Clinical Chemistry, University Hospital, SE-751 85 Uppsala, Sweden, Sweden aut Bergqvist D. Department of Surgery, University Hospital, SE-751 85 Uppsala, Sweden, Sweden aut Surgical Endoscopy Springer-Verlag 14/9(2000-09-01), 858-861 0930-2794 14:9<858 2000 14 464 https://doi.org/10.1007/s004640000213 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004640000213 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lindberg F. Department of Surgery, Skellefteå County Hospital, SE-931 86 Skellefteå, Sweden, Sweden aut NATIONALLICENCE 700 1- Rasmussen I. Department of Surgery, University Hospital, SE-751 85 Uppsala, Sweden, Sweden aut NATIONALLICENCE 700 1- Siegbahn A. Department of Clinical Chemistry, University Hospital, SE-751 85 Uppsala, Sweden, Sweden aut NATIONALLICENCE 700 1- Bergqvist D. Department of Surgery, University Hospital, SE-751 85 Uppsala, Sweden, Sweden aut NATIONALLICENCE 773 0- Surgical Endoscopy Springer-Verlag 14/9(2000-09-01), 858-861 0930-2794 14:9<858 2000 14 464 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer