caa a22 4500 475779347 CHVBK 20180406123640.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/s004640010074 doi (NATIONALLICENCE)springer-10.1007/s004640010074 Intraperitoneal tumor growth is influenced by pressure of carbon dioxide pneumoperitoneum [Elektronische Daten] [Ph. Wittich, E. W. Steyerberg, S. H. P. Simons, R. L. Marquet, H. J. Bonjer] Background: Several studies have indicated that the carbon dioxide (CO2) pneumoperitoneum during laparoscopy plays a role in the pathogenesis of port-site metastases. An experimental animal study was performed to investigate the impact of various pneumoperitoneum pressures on peritoneal tumor growth. Methods: In this study, 36 male WAG rats were randomized into three groups; two groups with different pneumoperitoneum pressures (16 mmHg and 4 mmHg) and one group of gasless controls. After a pneumoperitoneum of 0.5 × 106 ml was established, 531 tumor cells were injected intra-abdominally and the pneumoperitoneum was maintained for 60 min. Peritoneal tumor growth was assessed on day 11 at autopsy. Results: Peritoneal tumor growth in the 16-mmHg group was significantly greater than in the 4-mmHg group (p= 0.039) and the gasless group (p= 0.004). Conclusions: High-pressure CO2 pneumoperitoneum stimulates intra-abdominal tumor growth. The use of low insufflation pressures in laparoscopic cancer surgery should be considered. Springer-Verlag New York Inc., 2000 Key words: Carbon dioxide — Laparoscopy — Metastases — Pneumoperitoneum — Port site — Pressure nationallicence Wittich Ph Department of Surgery, University Hospital Rotterdam-Dijkzigt, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands, The Netherlands aut Steyerberg E. W. Department of Surgery, University Hospital Rotterdam-Dijkzigt, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands, The Netherlands aut Simons S. H. P. Department of Surgery, University Hospital Rotterdam-Dijkzigt, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands, The Netherlands aut Marquet R. L. Department of Surgery, University Hospital Rotterdam-Dijkzigt, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands, The Netherlands aut Bonjer H. J. Department of Surgery, University Hospital Rotterdam-Dijkzigt, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands, The Netherlands aut Surgical Endoscopy Springer-Verlag 14/9(2000-09-01), 817-819 0930-2794 14:9<817 2000 14 464 https://doi.org/10.1007/s004640010074 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004640010074 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wittich Ph Department of Surgery, University Hospital Rotterdam-Dijkzigt, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands, The Netherlands aut NATIONALLICENCE 700 1- Steyerberg E. W. Department of Surgery, University Hospital Rotterdam-Dijkzigt, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands, The Netherlands aut NATIONALLICENCE 700 1- Simons S. H. P. Department of Surgery, University Hospital Rotterdam-Dijkzigt, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands, The Netherlands aut NATIONALLICENCE 700 1- Marquet R. L. Department of Surgery, University Hospital Rotterdam-Dijkzigt, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands, The Netherlands aut NATIONALLICENCE 700 1- Bonjer H. J. Department of Surgery, University Hospital Rotterdam-Dijkzigt, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands, The Netherlands aut NATIONALLICENCE 773 0- Surgical Endoscopy Springer-Verlag 14/9(2000-09-01), 817-819 0930-2794 14:9<817 2000 14 464 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer