caa a22 4500 475779487 CHVBK 20180406123640.0 cr unu---uuuuu 170329e20000701xx s 000 0 eng 10.1007/s004640000144 doi (NATIONALLICENCE)springer-10.1007/s004640000144 Endoscopic photodynamic therapy for obstructing esophageal cancer: 77 cases over a 2-year period [Elektronische Daten] [J. D. Luketich, N. A. Christie, P. O. Buenaventura, T. L. Weigel, R. J. Keenan, N. T. Nguyen] rid=""id=""<e5>Correspondence to:</e5> J. D. Luketich, 200 Lothrop Street, C-800, Presbyterian Hospital, Pittsburgh, PA 15213, USA Background: Photodynamic therapy (PDT) is an alternative treatment option for the palliation of obstructive esophageal cancer. We report our experience with PDT for patients presenting with inoperable, obstructing, or bleeding esophageal cancer. Methods: Seventy-seven patients with inoperable, obstructing esophageal cancer were treated with PDT from November 1996 to July 1998. Photofrin (1.5-2.0 mg/kg) was administered, followed by endoscopic light treatment (630 nm red dye laser) at 48 h. Dysphagia score (1 for no dysphagia to 5 for complete obstruction), dysphagia-free interval, and patient survival were assessed. Results: Seventy-seven patients underwent 125 PDT courses. The mean dysphagia score at 4 weeks after PDT in 90.8% of the patients improved from 3.2 ± 0.7 to 1.9 ± 0.8 (p < 0.05). PDT adequately controlled bleeding in all six patients who had bleeding. The most common complications after the 125 PDT courses were esophageal stricture (4.8%), Candida esophagitis (3.2%), symptomatic pleural effusion (3.2%), and sunburn (10.0%). Twenty-nine patients (38%) required more than one PDT course, and seven patients required placement of an expandable metal stent for recurrent dysphagia. The mean dysphagia-free interval was 80.3 ± 58.2 days. The median survival was 5.9 months. Conclusions: Photodynamic therapy is a safe and effective treatment for the palliation of obstructing and bleeding esophagus cancer. Springer-Verlag New York Inc., 2000 Key words: Cancer — Endoscopy — Esophagus — Expandable metal stent — Palliation — Photodynamic therapy — Stent nationallicence Luketich J. D. Section of Thoracic Surgery and Minimally Invasive Surgery Center, University of Pittsburgh Medical Center, 200 Lothrop Street, C-800, Presbyterian Hospital, Pittsburgh, PA 15213, USA, USA aut Christie N. A. Section of Thoracic Surgery and Minimally Invasive Surgery Center, University of Pittsburgh Medical Center, 200 Lothrop Street, C-800, Presbyterian Hospital, Pittsburgh, PA 15213, USA, USA aut Buenaventura P. O. Section of Thoracic Surgery and Minimally Invasive Surgery Center, University of Pittsburgh Medical Center, 200 Lothrop Street, C-800, Presbyterian Hospital, Pittsburgh, PA 15213, USA, USA aut Weigel T. L. Section of Thoracic Surgery and Minimally Invasive Surgery Center, University of Pittsburgh Medical Center, 200 Lothrop Street, C-800, Presbyterian Hospital, Pittsburgh, PA 15213, USA, USA aut Keenan R. J. Section of Thoracic Surgery and Minimally Invasive Surgery Center, University of Pittsburgh Medical Center, 200 Lothrop Street, C-800, Presbyterian Hospital, Pittsburgh, PA 15213, USA, USA aut Nguyen N. T. Section of Thoracic Surgery and Minimally Invasive Surgery Center, University of Pittsburgh Medical Center, 200 Lothrop Street, C-800, Presbyterian Hospital, Pittsburgh, PA 15213, USA, USA aut Surgical Endoscopy Springer-Verlag 14/7(2000-07-01), 653-657 0930-2794 14:7<653 2000 14 464 https://doi.org/10.1007/s004640000144 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004640000144 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Luketich J. D. Section of Thoracic Surgery and Minimally Invasive Surgery Center, University of Pittsburgh Medical Center, 200 Lothrop Street, C-800, Presbyterian Hospital, Pittsburgh, PA 15213, USA, USA aut NATIONALLICENCE 700 1- Christie N. A. Section of Thoracic Surgery and Minimally Invasive Surgery Center, University of Pittsburgh Medical Center, 200 Lothrop Street, C-800, Presbyterian Hospital, Pittsburgh, PA 15213, USA, USA aut NATIONALLICENCE 700 1- Buenaventura P. O. Section of Thoracic Surgery and Minimally Invasive Surgery Center, University of Pittsburgh Medical Center, 200 Lothrop Street, C-800, Presbyterian Hospital, Pittsburgh, PA 15213, USA, USA aut NATIONALLICENCE 700 1- Weigel T. L. Section of Thoracic Surgery and Minimally Invasive Surgery Center, University of Pittsburgh Medical Center, 200 Lothrop Street, C-800, Presbyterian Hospital, Pittsburgh, PA 15213, USA, USA aut NATIONALLICENCE 700 1- Keenan R. J. Section of Thoracic Surgery and Minimally Invasive Surgery Center, University of Pittsburgh Medical Center, 200 Lothrop Street, C-800, Presbyterian Hospital, Pittsburgh, PA 15213, USA, USA aut NATIONALLICENCE 700 1- Nguyen N. T. Section of Thoracic Surgery and Minimally Invasive Surgery Center, University of Pittsburgh Medical Center, 200 Lothrop Street, C-800, Presbyterian Hospital, Pittsburgh, PA 15213, USA, USA aut NATIONALLICENCE 773 0- Surgical Endoscopy Springer-Verlag 14/7(2000-07-01), 653-657 0930-2794 14:7<653 2000 14 464 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer