caa a22 4500 475779711 CHVBK 20180406123641.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/s004640000239 doi (NATIONALLICENCE)springer-10.1007/s004640000239 Gastric malt lymphomas: the value of an endoscopic follow-up evaluation [Elektronische Daten] [F. Agresta, G. Trentin, P. Mainente, D. Della Libera, A. Bianco, L. Salvagno] Background: Findings have demonstrated the close association between primary gastric B-cell lymphomas originating from mucosa-associated lymphoid tissue (MALT) and Helicobacter pylori (HP) infection, with their regression after an HP eradication therapy in up to 70% of the cases. Endoscopic-biopsy diagnosis and endoscopic ultrasound are of major importance as decisive prognostic factors and therapeutic determinants. Objectives: We report 3 years of experience and follow-up evaluation in the management of MALT lymphomas. We also describe the guidelines strategy therapy used in our institution. Methods: Since July 1996, nine patients with a histologic diagnosis of low-grade, HP-positive MALT gastric lymphomas, have been followed up. All patients had stage IE lymphomas (according to Musshoff classification). Eradication of HP was performed with triple therapy amoxycillin, clarithromycin, and omeprazole using over a 14-day period. The patients were seen for endoscopic follow-up assessment after 3, 6, 9, and 15 months, then twice a year. The actual median follow-up time was 30.4 months (range, 16-38 months). Results: All the patients are now free of disease and asymptomatic. We have registered two cases of HP relapse (both after 1-year follow-up evaluation), positively treated with the same triple therapy, and three cases of disease relapse treated with single-dose chemotherapy (plus radiotherapy in one patient). Conclusions: In our experience the eradication of HP appears to be effective, and we consider it the first therapeutic option in patients with stage IE gastric low-grade MALT lymphoma, although long-term results are still needed. Prolonged follow-up evaluation (particularly by endoscopy) is necessary (and feasible in our experience) to determine whether these remissions are long-lasting. We recommend that HP be eradicated in these lymphomas before referral to other standard treatment. Springer-Verlag New York Inc., 2000 Key words: Gastric malt lymphomas —Helicobacter pylori nationallicence Agresta F. Endoscopic Unit, Department of General Surgery, Civil Hospital, Vittorio Veneto (TV), Italy, IT aut Trentin G. Endoscopic Unit, Department of General Surgery, Civil Hospital, Vittorio Veneto (TV), Italy, IT aut Mainente P. Endoscopic Unit, Department of General Surgery, Civil Hospital, Vittorio Veneto (TV), Italy, IT aut Della Libera D. Department of Histopathology, Civil Hospital, Conegliano (TV), Italy, IT aut Bianco A. Department of Oncology, Civil Hospital, Vittorio Veneto (TV), Italy, IT aut Salvagno L. Department of Oncology, Civil Hospital, Vittorio Veneto (TV), Italy, IT aut Surgical Endoscopy Springer-Verlag 14/12(2000-12-01), 1153-1155 0930-2794 14:12<1153 2000 14 464 https://doi.org/10.1007/s004640000239 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004640000239 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Agresta F. Endoscopic Unit, Department of General Surgery, Civil Hospital, Vittorio Veneto (TV), Italy, IT aut NATIONALLICENCE 700 1- Trentin G. Endoscopic Unit, Department of General Surgery, Civil Hospital, Vittorio Veneto (TV), Italy, IT aut NATIONALLICENCE 700 1- Mainente P. Endoscopic Unit, Department of General Surgery, Civil Hospital, Vittorio Veneto (TV), Italy, IT aut NATIONALLICENCE 700 1- Della Libera D. Department of Histopathology, Civil Hospital, Conegliano (TV), Italy, IT aut NATIONALLICENCE 700 1- Bianco A. Department of Oncology, Civil Hospital, Vittorio Veneto (TV), Italy, IT aut NATIONALLICENCE 700 1- Salvagno L. Department of Oncology, Civil Hospital, Vittorio Veneto (TV), Italy, IT aut NATIONALLICENCE 773 0- Surgical Endoscopy Springer-Verlag 14/12(2000-12-01), 1153-1155 0930-2794 14:12<1153 2000 14 464 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer