caa a22 4500 475779967 CHVBK 20180406123641.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s004640000047 doi (NATIONALLICENCE)springer-10.1007/s004640000047 Pneumoperitoneum with carbon dioxide enhances liver metastases of cancer cells implanted into the portal vein in rabbits [Elektronische Daten] [H. Ishida, N. Murata, H. Yamada, H. Nakada, I. Takeuchi, K. Shimomura, M. Fujioka, Y. Idezuki] Background: Little is known about the role of the CO2 pneumoperitoneum on tumor cells that spread from the portal system into the liver during laparoscopic surgery for gastrointestinal malignancies. Therefore, we designed a study to investigate the effect of CO2 pneumoperitoneum on cancer cells implanted in the portal vein in a rabbit model. Methods: Immediately after intraportal inoculation of 2.5 × 105 cells of VX2 cancer, the rabbits received either CO2 pneumoperitoneum at a pressure of 10 mmHg for 30 min (pneumoperitoneum group, n= 14) or laparotomy alone for 30 min (laparotomy group, n= 14). Results: The number (p < 0.01) and area of cancer nodules (p= 0.045) on the liver surface on day 17 were greater in the pneumoperitoneum group than in the laparotomy group. The frequency of cancer nodules >3.0 mm in diameter was higher in the pneumoperitoneum group than in the laparotomy group (p < 0.001). Conclusions: Compared with laparotomy, CO2 pneumoperitoneum enhanced the development of liver metastases in this experimental model. Springer-Verlag New York Inc., 2000 Key words: Laparoscopic surgery — CO2 pneumoperitoneum — Liver metastasis — Gastrointestinal cancer — VX2 cancer nationallicence Ishida H. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, Japan aut Murata N. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, Japan aut Yamada H. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, Japan aut Nakada H. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, Japan aut Takeuchi I. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, Japan aut Shimomura K. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, Japan aut Fujioka M. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, Japan aut Idezuki Y. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, Japan aut Surgical Endoscopy Springer-Verlag 14/3(2000-03-01), 239-242 0930-2794 14:3<239 2000 14 464 https://doi.org/10.1007/s004640000047 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004640000047 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ishida H. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, Japan aut NATIONALLICENCE 700 1- Murata N. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, Japan aut NATIONALLICENCE 700 1- Yamada H. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, Japan aut NATIONALLICENCE 700 1- Nakada H. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, Japan aut NATIONALLICENCE 700 1- Takeuchi I. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, Japan aut NATIONALLICENCE 700 1- Shimomura K. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, Japan aut NATIONALLICENCE 700 1- Fujioka M. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, Japan aut NATIONALLICENCE 700 1- Idezuki Y. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Kawagoe, Saitama, 350-8550, Japan, Japan aut NATIONALLICENCE 773 0- Surgical Endoscopy Springer-Verlag 14/3(2000-03-01), 239-242 0930-2794 14:3<239 2000 14 464 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer