caa a22 4500 475780957 CHVBK 20180406123644.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/s004640000145 doi (NATIONALLICENCE)springer-10.1007/s004640000145 Long-term prognosis of gallbladder cancer diagnosed after laparoscopic cholecystectomy [Elektronische Daten] [K. Suzuki, T. Kimura, H. Ogawa] Background: Several clinical and laboratory studies concerning port-site recurrence have raised the concern that laparoscopic procedures might worsen the prognosis of malignant disease. However, the long-term prognosis of patients with malignancy who undergo laparoscopic surgery is still unknown. The purpose of this study was to examine the long-term prognosis of patients with unexpected gallbladder cancer diagnosed after laparoscopic cholecystectomy (LC). Methods: A clinicopathologic study was performed on 41 patients with postoperatively diagnosed gallbladder cancer from among 5,027 patients undergoing LC at 24 institutions. The cumulative survival rate was compared with that reported for gallbladder cancer diagnosed after open cholecystectomy (OC). Results: Of 26 patients with early gallbladder cancer (pTis or pT1), 23 were simply followed up, and 9 of 15 patients with advanced cancer (pT2 or pT3) had additional resection after the diagnosis of gallbladder cancer. Port-site recurrence occurred in four patients, and two of them died of the cancer. However, at this writing, the other two are still alive after abdominal wall resection or radiation therapy, having survived for 31 and 71 months, respectively. The 5-year survival rate was 92% for early cancer and 59% for advanced cancer. These results were comparable with 5-year survival rates for gallbladder cancer diagnosed after OC. Conclusions: Although port-site recurrence occurred in four patients with advanced gallbladder cancer, the long-term prognosis of patients with undiagnosed gallbladder cancer who underwent LC was not worsened by the laparoscopic procedure. We conclude that surgeons can perform LC with reasonable confidence, even if the lesion is possibly malignant. Springer-Verlag, 2000 Laparoscopic cholecystectomy nationallicence Long-term prognosis nationallicence Multicenter study nationallicence Undiagnosed gallbladder cancer nationallicence Suzuki K. Shizuoka Study Group for Endoscopic Surgery, First Department of Surgery, Fujimnomiya City General Hospital, 3-1 Nishiki-cho, 418-0076, Fujinomiya, Japan aut Kimura T. Shizuoka Study Group for Endoscopic Surgery, First Department of Surgery, Fujimnomiya City General Hospital, 3-1 Nishiki-cho, 418-0076, Fujinomiya, Japan aut Ogawa H. Department of Pathology, Srirei Mikitabara General Hospital, 3452 Mikitabara-cho, 433-8105, Hamamatsu, Japan aut Surgical Endoscopy Springer-Verlag 14/8(2000-08-01), 712-716 0930-2794 14:8<712 2000 14 464 https://doi.org/10.1007/s004640000145 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004640000145 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Suzuki K. Shizuoka Study Group for Endoscopic Surgery, First Department of Surgery, Fujimnomiya City General Hospital, 3-1 Nishiki-cho, 418-0076, Fujinomiya, Japan aut NATIONALLICENCE 700 1- Kimura T. Shizuoka Study Group for Endoscopic Surgery, First Department of Surgery, Fujimnomiya City General Hospital, 3-1 Nishiki-cho, 418-0076, Fujinomiya, Japan aut NATIONALLICENCE 700 1- Ogawa H. Department of Pathology, Srirei Mikitabara General Hospital, 3452 Mikitabara-cho, 433-8105, Hamamatsu, Japan aut NATIONALLICENCE 773 0- Surgical Endoscopy Springer-Verlag 14/8(2000-08-01), 712-716 0930-2794 14:8<712 2000 14 464 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer