caa a22 4500 475781325 CHVBK 20180406123645.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s004640000160 doi (NATIONALLICENCE)springer-10.1007/s004640000160 Fluorescence diagnosis of endometriosis using 5-aminolevulinic acid [Elektronische Daten] [E. Malik, C. Berg, A. Meyhöfer-Malik, O. Buchweitz, P. Moubayed, K. Diedrich] Background: The diagnosis of nonpigmented endometrial lesions by simple laparoscopic visualization is difficult and often inaccurate. We therefore sought to establish a new and more accurate method to visualize these nonpigmented peritoneal changes caused by endometriosis. Methods: A total of 37 patients received 30 mg 5-aminolevulinic acid/kg body weight 10 to 14 hs prior to surgery. Laparoscopy was then performed using a D-light system (Storz, Tuttlingen, Germany). The findings were evaluated first in the white-light mode; the D-light system was then activated, and all areas of fluorescence were documented. Multiple specimens were obtained by biopsy. Results: The sensitivity of the fluorescence diagnosis in detecting endometriosis in nonpigmented areas and normal-looking peritoneum is 100%, with a specificity of 75%. Diagnosis by simple visualization under white illumination has a sensitivity of only 69% and a specificity of 70%. Occult areas of endometriosis were discovered using fluorescence diagnosis. Conclusions: Our findings suggest that fluorescence diagnosis using 5-aminolevulinic acid is feasible and can improve the diagnosis of endometriosis in nonpigmented and occult endometrial lesions. Fluorescence diagnosis is a promising new tool in the diagnosis of endometriosis. Springer-Verlag New York Inc., 2000 Key words: Fluorescence diagnosis — Endometriosis — 5-aminolevulinic acid — Fluorescence — Photodynamic diagnosis nationallicence Malik E. Department of Obstetrics and Gynecology, Medical University Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany, DE aut Berg C. Department of Obstetrics and Gynecology, Medical University Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany, DE aut Meyhöfer-Malik A. Department of Obstetrics and Gynecology, Medical University Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany, DE aut Buchweitz O. Department of Obstetrics and Gynecology, Medical University Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany, DE aut Moubayed P. Institute of Pathology, Medical University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany, DE aut Diedrich K. Department of Obstetrics and Gynecology, Medical University Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany, DE aut Surgical Endoscopy Springer-Verlag 14/5(2000-05-01), 452-455 0930-2794 14:5<452 2000 14 464 https://doi.org/10.1007/s004640000160 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004640000160 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Malik E. Department of Obstetrics and Gynecology, Medical University Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany, DE aut NATIONALLICENCE 700 1- Berg C. Department of Obstetrics and Gynecology, Medical University Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany, DE aut NATIONALLICENCE 700 1- Meyhöfer-Malik A. Department of Obstetrics and Gynecology, Medical University Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany, DE aut NATIONALLICENCE 700 1- Buchweitz O. Department of Obstetrics and Gynecology, Medical University Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany, DE aut NATIONALLICENCE 700 1- Moubayed P. Institute of Pathology, Medical University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany, DE aut NATIONALLICENCE 700 1- Diedrich K. Department of Obstetrics and Gynecology, Medical University Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany, DE aut NATIONALLICENCE 773 0- Surgical Endoscopy Springer-Verlag 14/5(2000-05-01), 452-455 0930-2794 14:5<452 2000 14 464 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer