caa a22 4500 47578149X CHVBK 20180406123645.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1007/s004649900099 doi (NATIONALLICENCE)springer-10.1007/s004649900099 Influence of trocar placement and CO2 pneumoperitoneum on port site metastasis following laparoscopic tumor surgery [Elektronische Daten] [H. Ishida, N. Murata, H. Yamada, T. Nomura, K. Shimomura, M. Fujioka, Y. Idezuki] Background: The mechanisms involved in the development of port site metastasis following laparoscopic tumor surgery remain controversial. Therefore, we decided to investigate the influence of trocar placement and CO2 pneumoperitoneum on abdominal wound implantation in relation to intraperitoneal tumor growth in a rabbit model. Methods: Rabbits received either CO2 pneumoperitoneum with insertion of nine trocars (pneumoperitoneum group, n= 15), insertion of nine trocars alone (nonpneumoperitoneum group, n= 15), or nine abdominal incisions (control group, n= 13) 3 days after intraperitoneal inoculation of VX2 cancer cells. Results: The frequency of overall wound implantation on day 17 in the pneumoperitoneum group (24.4%) and nonpneumoperitoneum group (27.4%) tended to be higher than that in the control group (15.3%) (p= 0.06). There was no significant difference among the three groups in the growth of cancer nodules on the omentum. Conclusions: The presence of a trocar may be a factor contributing to port site metastasis but CO2 pneumoperitoneum appears not to be a factor. Springer-Verlag New York Inc., 2000 Key words: Port site metastasis — Abdominal wound metastasis — Laparoscopic surgery — Pneumoperitoneum — VX2 cancer — Tumor surgery nationallicence Ishida H. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe, Saitama, 350-0885, Japan, Japan aut Murata N. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe, Saitama, 350-0885, Japan, Japan aut Yamada H. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe, Saitama, 350-0885, Japan, Japan aut Nomura T. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe, Saitama, 350-0885, Japan, Japan aut Shimomura K. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe, Saitama, 350-0885, Japan, Japan aut Fujioka M. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe, Saitama, 350-0885, Japan, Japan aut Idezuki Y. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe, Saitama, 350-0885, Japan, Japan aut Surgical Endoscopy Springer-Verlag 14/2(2000-02-01), 193-197 0930-2794 14:2<193 2000 14 464 https://doi.org/10.1007/s004649900099 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004649900099 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ishida H. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe, Saitama, 350-0885, Japan, Japan aut NATIONALLICENCE 700 1- Murata N. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe, Saitama, 350-0885, Japan, Japan aut NATIONALLICENCE 700 1- Yamada H. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe, Saitama, 350-0885, Japan, Japan aut NATIONALLICENCE 700 1- Nomura T. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe, Saitama, 350-0885, Japan, Japan aut NATIONALLICENCE 700 1- Shimomura K. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe, Saitama, 350-0885, Japan, Japan aut NATIONALLICENCE 700 1- Fujioka M. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe, Saitama, 350-0885, Japan, Japan aut NATIONALLICENCE 700 1- Idezuki Y. Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe, Saitama, 350-0885, Japan, Japan aut NATIONALLICENCE 773 0- Surgical Endoscopy Springer-Verlag 14/2(2000-02-01), 193-197 0930-2794 14:2<193 2000 14 464 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer