caa a22 4500 475781872 CHVBK 20180406123646.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1007/s004640000219 doi (NATIONALLICENCE)springer-10.1007/s004640000219 Choice of insufflating gas influences on wound metastasisrid=""id=""Presented at the annual meeting of the Society of American Gastrointestinal Endoscopic Surgeons (SAGES), San Antonio, Texas, USA, March 1999 [Elektronische Daten] [T. M. Farrell, R. E. Metreveli, A. B. Johnson, C. D. Smith, J. G. Hunter] Background: Laparoscopic cancer surgery is limited by concerns about port-site metastasis. No study has definitively addressed the behavior and growth of tumor cells after the use of specific laparoscopic gases. Methods: In athymic rats, 10,000 colon cancer cells were injected intraperitoneally. The rats received either no pneumoperitoneum (pneumo) or pneumo (8 mmHg, 10 min) with carbon dioxide (CO2), nitrous oxide (N2O), or air. Two full-thickness incisions were made and closed in the upper abdomen of each animal. After 4 weeks, implants were identified grossly at necropsy, and invasiveness was scored according to penetration through the layers of the abdominal wall. Results: Rats receiving pneumo had more frequent implants (p < 0.01) with deeper penetration (p < 0.001) than rats not receiving pneumo. Implants were more common after air pneumo than after CO2 (p < 0.05) or N2O (p= 0.07) pneumo, and were less penetrating after CO2 pneumo than after air (p < 0.001) or N2O (p < 0.05) pneumo. Conclusions: Carbon dioxide gas may limit the viability and invasiveness of free intraperitoneal tumor cells, as compared with air or N2O. Springer-Verlag New York Inc., 2000 Key words: Colon cancer — Gases — Implantation — Laparoscopy — Pneumoperitoneum — Port site nationallicence Farrell T. M. Department of Surgery, University of North Carolina at Chapel Hill, Campus Box 7210, Burnett Womack Clinical Sciences Building, Chapel Hill, NC 27599-7210, USA, US aut Metreveli R. E. Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA, US aut Johnson A. B. Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA, US aut Smith C. D. Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA, US aut Hunter J. G. Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA, US aut https://doi.org/10.1007/s004640000219 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004640000219 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Farrell T. M. Department of Surgery, University of North Carolina at Chapel Hill, Campus Box 7210, Burnett Womack Clinical Sciences Building, Chapel Hill, NC 27599-7210, USA, US aut NATIONALLICENCE 700 1- Metreveli R. E. Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA, US aut NATIONALLICENCE 700 1- Johnson A. B. Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA, US aut NATIONALLICENCE 700 1- Smith C. D. Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA, US aut NATIONALLICENCE 700 1- Hunter J. G. Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer