caa a22 4500 475782291 CHVBK 20180406123647.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1023/A:1008981517743 doi (NATIONALLICENCE)springer-10.1023/A:1008981517743 Evaluation of the acute scarring response to the implant of different types of biomaterial in the abdominal wall [Elektronische Daten] [J. Bello´n, L. Contreras, G. Pascual, J. Buja´n] Since the short-term, acute scarring process induced by a biomaterial may condition the evolution of the repair process, the present investigation evaluates the behavior of polytetrafluoroethylene (PTFE) and polypropylene (PL) biomaterials in the initial stages of repair. Three PTFE biomaterials (Mycro Mesh®, Dual Mesh® and Soft Tissue Patch®) and one PL biomaterial (Marlex®) were employed to repair defects created in the abdominal wall of New Zealand rabbits. Animals were sacrificed at 3 or 7 days. Specimens were obtained for light and scanning electron microscopy, and immunohistochemical analysis using the RAM-11 monoclonal antibody for rabbit macrophages. The PL implants showed substantial adhesion formation with viscera. Lower adhesion formation was detected in the PTFE implants. The evolution of the acute phase of the repair process was similar for each PTFE biomaterial. At 3 days post implant, an incipient neoperitoneum was detected which was fully established after 7 days. The behavior of the PL implant was similar, although a greater amount of reticular granulation was detected. The neoformed peritoneum was irregular. Few RAM-11-labeled macrophages were detected in all cases. The acute phase of the tissue repair process induced by the implant of PTFE and PL biomaterials generally proceeds along similar lines to a normal repair process. However, the use of microporous, laminar materials seems to favor the early establishment of a well-defined neoperitoneal layer. Kluwer Academic Publishers, 2000 Bello´n J. Department of Morphological Sciences and Surgery, Faculty of Medicine, University of Alcala´, Madrid, Spain aut Contreras L. Department of Morphological Sciences and Surgery, Faculty of Medicine, University of Alcala´, Madrid, Spain aut Pascual G. Department of Morphological Sciences and Surgery, Faculty of Medicine, University of Alcala´, Madrid, Spain aut Buja´n J. Department of Morphological Sciences and Surgery, Faculty of Medicine, University of Alcala´, Madrid, Spain aut Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/1(2000-01-01), 25-29 0957-4530 11:1<25 2000 11 10856 https://doi.org/10.1023/A:1008981517743 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1008981517743 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bello´n J. Department of Morphological Sciences and Surgery, Faculty of Medicine, University of Alcala´, Madrid, Spain aut NATIONALLICENCE 700 1- Contreras L. Department of Morphological Sciences and Surgery, Faculty of Medicine, University of Alcala´, Madrid, Spain aut NATIONALLICENCE 700 1- Pascual G. Department of Morphological Sciences and Surgery, Faculty of Medicine, University of Alcala´, Madrid, Spain aut NATIONALLICENCE 700 1- Buja´n J. Department of Morphological Sciences and Surgery, Faculty of Medicine, University of Alcala´, Madrid, Spain aut NATIONALLICENCE 773 0- Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/1(2000-01-01), 25-29 0957-4530 11:1<25 2000 11 10856 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer