caa a22 4500 475782356 CHVBK 20180406123648.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1023/A:1008990109419 doi (NATIONALLICENCE)springer-10.1023/A:1008990109419 Controlled release systems based on poly(lactic acid). An in vitro and in vivo study [Elektronische Daten] [A.G. Andreopoulos, E. Hatzi, M. Doxastakis] A new biodegradable delivery system based on poly(lactic acid) has been formulated, with potential applications in sustained antibiotic release against bone infection. The in vitro release of a new quinolone (pefloxacin) from low molecular weight poly(D,L-lactic acid) Mw = 2×103 lasted for 56 d whereas the in vivo delivery lasted 33 d. In both cases, the release rate is controlled by the drug diffusion and the polymer degradation, which seems to be the predominant factor. For the release experiments, discs were prepared from poly (D,L-lactide) Mw = 2×104 with drug loadings of 2% and 10% w/w. It was concluded that pefloxacin concentration remains higher than the Minimum Inhibitory Concentration (MIC) against the major causative bacteria of bone infection. The results indicate that the two different types of poly(lactic acid) can be used effectively in an implantable antibiotic release system. ©2000 Kluwer Academic Publishers Kluwer Academic Publishers, 2000 Andreopoulos A.G. Department of Chemical Engineering, National Technical University of Athens, 9 Iroon Polytechniou Str, 15780, Athens, Greece aut Hatzi E. Department of Chemical Engineering, National Technical University of Athens, 9 Iroon Polytechniou Str, 15780, Athens, Greece aut Doxastakis M. Department of Chemical Engineering, National Technical University of Athens, 9 Iroon Polytechniou Str, 15780, Athens, Greece aut Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/6(2000-06-01), 393-397 0957-4530 11:6<393 2000 11 10856 https://doi.org/10.1023/A:1008990109419 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1008990109419 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Andreopoulos A.G. Department of Chemical Engineering, National Technical University of Athens, 9 Iroon Polytechniou Str, 15780, Athens, Greece aut NATIONALLICENCE 700 1- Hatzi E. Department of Chemical Engineering, National Technical University of Athens, 9 Iroon Polytechniou Str, 15780, Athens, Greece aut NATIONALLICENCE 700 1- Doxastakis M. Department of Chemical Engineering, National Technical University of Athens, 9 Iroon Polytechniou Str, 15780, Athens, Greece aut NATIONALLICENCE 773 0- Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/6(2000-06-01), 393-397 0957-4530 11:6<393 2000 11 10856 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer