caa a22 4500 475782437 CHVBK 20180406123648.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1023/A:1008932303913 doi (NATIONALLICENCE)springer-10.1023/A:1008932303913 The effect of osteopenia on the osteointegration of different biomaterials: histomorphometric study in rats [Elektronische Daten] [M. Fini, G. Giavaresi, N. Aldini, P. Torricelli, G. Morrone, G.-A. Guzzardella, R. Giardino, A. Krajewski, A. Ravaglioli, M. Belmonte, A. Benedittis, G. Biagini] The osteointegration of Hydroxyapatite (HA), Titanium (Ti-6Al-4V: Ti), Zirconia (ZrO2), Alumina (Al2O3) and 2 biological glasses (AP40 and RKKP) was comparatively investigated in normal and osteopenic rats by means of histomorphometry. Thirty-six Sprague Dawley female rats were left intact (Group C) while 36 were ovariectomized (Group OVX). Group C and OVX were further divided into 6 subgroups. After 16 weeks all animals were submitted to the femoral implant of nails made of the above-mentioned materials. Eight weeks after implantation the animals were euthanized, the femurs were harvested for histomorphometric analysis. The data showed that: (1) all the tested materials were biocompatible in vitro; (2) no significant differences existed in Affinity Index (AI) of Group C; and (3) results from paired comparison applied to the AI showed significant differences among the Groups C and OVX. The AI did not significantly change among intact groups, while it significantly decreased when some materials were implanted in OVX subgroups (AP40, ZrO2 and Ti-6Al-4V: $${p < 0.0005}$$ , $${p < 0.05}$$ and $${p < 0.01}$$ ). It is confirmed that bone mineral density is a strong predictor of the osteointegration of an orthopedic implant and that the use of pathological animal models is necessary to completely characterize biomaterials. Kluwer Academic Publishers, 2000 Fini M. Experimental Surgery Department and Chair of Surgical Pathophysiology, University of Bologna, Research Institute Codivilla-Putti, Rizzoli Orthopedic Institute (I.O.R.), Via Di Barbiano 1/10, 40136, Bologna, Italy aut Giavaresi G. Experimental Surgery Department and Chair of Surgical Pathophysiology, University of Bologna, Research Institute Codivilla-Putti, Rizzoli Orthopedic Institute (I.O.R.), Via Di Barbiano 1/10, 40136, Bologna, Italy aut Aldini N. Experimental Surgery Department and Chair of Surgical Pathophysiology, University of Bologna, Research Institute Codivilla-Putti, Rizzoli Orthopedic Institute (I.O.R.), Via Di Barbiano 1/10, 40136, Bologna, Italy aut Torricelli P. Experimental Surgery Department and Chair of Surgical Pathophysiology, University of Bologna, Research Institute Codivilla-Putti, Rizzoli Orthopedic Institute (I.O.R.), Via Di Barbiano 1/10, 40136, Bologna, Italy aut Morrone G. Experimental Surgery Department and Chair of Surgical Pathophysiology, University of Bologna, Research Institute Codivilla-Putti, Rizzoli Orthopedic Institute (I.O.R.), Via Di Barbiano 1/10, 40136, Bologna, Italy aut Guzzardella G.-A Experimental Surgery Department and Chair of Surgical Pathophysiology, University of Bologna, Research Institute Codivilla-Putti, Rizzoli Orthopedic Institute (I.O.R.), Via Di Barbiano 1/10, 40136, Bologna, Italy aut Giardino R. Experimental Surgery Department and Chair of Surgical Pathophysiology, University of Bologna, Research Institute Codivilla-Putti, Rizzoli Orthopedic Institute (I.O.R.), Via Di Barbiano 1/10, 40136, Bologna, Italy aut Krajewski A. Institute for Technological Research on Ceramics of CNR, Faenza-, Italy aut Ravaglioli A. Institute for Technological Research on Ceramics of CNR, Faenza-, Italy aut Belmonte M. CIBAD Center for Innovative Biomaterials of Ancona, Italy aut Benedittis A. CIBAD Center for Innovative Biomaterials of Ancona, Italy aut Biagini G. CIBAD Center for Innovative Biomaterials of Ancona, Italy aut Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/9(2000-09-01), 579-585 0957-4530 11:9<579 2000 11 10856 https://doi.org/10.1023/A:1008932303913 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1008932303913 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fini M. Experimental Surgery Department and Chair of Surgical Pathophysiology, University of Bologna, Research Institute Codivilla-Putti, Rizzoli Orthopedic Institute (I.O.R.), Via Di Barbiano 1/10, 40136, Bologna, Italy aut NATIONALLICENCE 700 1- Giavaresi G. Experimental Surgery Department and Chair of Surgical Pathophysiology, University of Bologna, Research Institute Codivilla-Putti, Rizzoli Orthopedic Institute (I.O.R.), Via Di Barbiano 1/10, 40136, Bologna, Italy aut NATIONALLICENCE 700 1- Aldini N. Experimental Surgery Department and Chair of Surgical Pathophysiology, University of Bologna, Research Institute Codivilla-Putti, Rizzoli Orthopedic Institute (I.O.R.), Via Di Barbiano 1/10, 40136, Bologna, Italy aut NATIONALLICENCE 700 1- Torricelli P. Experimental Surgery Department and Chair of Surgical Pathophysiology, University of Bologna, Research Institute Codivilla-Putti, Rizzoli Orthopedic Institute (I.O.R.), Via Di Barbiano 1/10, 40136, Bologna, Italy aut NATIONALLICENCE 700 1- Morrone G. Experimental Surgery Department and Chair of Surgical Pathophysiology, University of Bologna, Research Institute Codivilla-Putti, Rizzoli Orthopedic Institute (I.O.R.), Via Di Barbiano 1/10, 40136, Bologna, Italy aut NATIONALLICENCE 700 1- Guzzardella G.-A Experimental Surgery Department and Chair of Surgical Pathophysiology, University of Bologna, Research Institute Codivilla-Putti, Rizzoli Orthopedic Institute (I.O.R.), Via Di Barbiano 1/10, 40136, Bologna, Italy aut NATIONALLICENCE 700 1- Giardino R. Experimental Surgery Department and Chair of Surgical Pathophysiology, University of Bologna, Research Institute Codivilla-Putti, Rizzoli Orthopedic Institute (I.O.R.), Via Di Barbiano 1/10, 40136, Bologna, Italy aut NATIONALLICENCE 700 1- Krajewski A. Institute for Technological Research on Ceramics of CNR, Faenza-, Italy aut NATIONALLICENCE 700 1- Ravaglioli A. Institute for Technological Research on Ceramics of CNR, Faenza-, Italy aut NATIONALLICENCE 700 1- Belmonte M. CIBAD Center for Innovative Biomaterials of Ancona, Italy aut NATIONALLICENCE 700 1- Benedittis A. CIBAD Center for Innovative Biomaterials of Ancona, Italy aut NATIONALLICENCE 700 1- Biagini G. CIBAD Center for Innovative Biomaterials of Ancona, Italy aut NATIONALLICENCE 773 0- Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/9(2000-09-01), 579-585 0957-4530 11:9<579 2000 11 10856 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer