caa a22 4500 475782658 CHVBK 20180406123649.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1023/A:1008953529111 doi (NATIONALLICENCE)springer-10.1023/A:1008953529111 Biomechanical and biological properties of the implant material carbon-carbon composite covered with pyrolytic carbon [Elektronische Daten] [V. PesÁkovÁ, Z. Kle´zl, K. Bali´k, M. Adam] The aim of this study was to test C/C material (carbonized, graphitized or covered with pyrolytic carbon) designated for the use in orthopaedic and bone surgery. Using an in vitro assay we confirmed, that the cell proliferation was exhibited the mostly on the C/C composite coated with pyrolitic carbon and afterwards polished. The two latest of subsequent water extracts of this material had a slightly inhibiting effect on the cells metabolic activity. Biocompatibility test in vivo performed subcutaneously on rats did not show big differences between three tested implants (C/C composite, epoxy resine, titanium alloy), on the other hand the plates tested on pigs demonstrated foreign-body reaction induced by wear C/C composite material. Such debris were found both in the neighborhood of the implant as well as in the lymphatic node. Kluwer Academic Publishers, 2000 PesÁkovÁ V. Rheumatism Institute, Na Slupi 4, 12850, Prague 2, Czech Republic aut Kle´zl Z. Orthopaedic-Traumatology Department, Central Military Hospital, U vojenske´ nemocnice 1, Prague 6, Czech Republic aut Bali´k K. Institute of Rock Structure and Mechanics, Acad. Sci. CR, V Holesovicka´ch 41, 18209, Prague 8, Czech Republic aut Adam M. Rheumatism Institute, Na Slupi 4, 12850, Prague 2, Czech Republic aut Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/12(2000-12-01), 793-798 0957-4530 11:12<793 2000 11 10856 https://doi.org/10.1023/A:1008953529111 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1008953529111 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- PesÁkovÁ V. Rheumatism Institute, Na Slupi 4, 12850, Prague 2, Czech Republic aut NATIONALLICENCE 700 1- Kle´zl Z. Orthopaedic-Traumatology Department, Central Military Hospital, U vojenske´ nemocnice 1, Prague 6, Czech Republic aut NATIONALLICENCE 700 1- Bali´k K. Institute of Rock Structure and Mechanics, Acad. Sci. CR, V Holesovicka´ch 41, 18209, Prague 8, Czech Republic aut NATIONALLICENCE 700 1- Adam M. Rheumatism Institute, Na Slupi 4, 12850, Prague 2, Czech Republic aut NATIONALLICENCE 773 0- Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/12(2000-12-01), 793-798 0957-4530 11:12<793 2000 11 10856 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer