caa a22 4500 475782801 CHVBK 20180406123649.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1023/A:1008970116308 doi (NATIONALLICENCE)springer-10.1023/A:1008970116308 Plain and drug loaded polyphosphazene membranes and microspheres in the treatment of rabbit bone defects [Elektronische Daten] [P. Passi, A. Zadro, F. Marsilio, S. Lora, P. Caliceti, F. Veronese] The healing of periodontal surgical defects was studied in rabbits, using polyphosphazenes (POP) membranes and microspheres, both plain or drug-enriched. POP polymers having amino acid ester as backbone substituents, are used since they resorb and undergo hydrolytic degradation to ammonia, phosphate and amino acids. Fourteen animal were operated in tibia, and other fourteen at angle of the mandible, that was reached by extraoral access. Bone defects were performed in tibiae, and covered either with POP or with poly-tetrafluoroethylene (PTFE) membranes, while other rabbits served as controls. The animals were sacrificed after one and two months, and the tibiae taken and processed for optical microscopy. Similar surgical defects were made in mandible, and POP membranes were placed over the breaches, some of which were filled with POP microspheres, both alone or mixed with granular hydroxyapatite. For comparison, two rabbits were treated with PTFE membranes, while other two served as controls. The animals operated at the mandible were all sacrificed after one month, and the operated bones taken and processed for histology. It was found that POP membranes were very effective in promoting the healing in tibiae, while less satisfactory results were found in the animals treated with PTFE membranes and in controls. In mandible, the healing occurred without a clear relationship with the grafted microgranular material or the membrane, since repairing bone was found also in controls. In any case, both POP membranes and microspheres showed excellent biocompatibility, as no inflammatory cells or macrophages were found in the surrounding tissue. This property was completely independent from the presence of drug, since the matrix-entrapped drugs, released in the tissue, did not hamper the bone healing. It was also found that POP, by itself, has a positive effect in stimulating the bone repair. Kluwer Academic Publishers, 2000 Passi P. Dental School, Department of Dental Materials, University of Padua, Italy aut Zadro A. Dental School, Department of Dental Materials, University of Padua, Italy aut Marsilio F. Department of Pharmaceutical Sciences (CNR Center for Drugs and Biological Products), University of Padua, Italy aut Lora S. Istituto di Fotochimica e Radiazioni d' Alta Energia del CNR, Legnaro, Padua, Italy aut Caliceti P. Department of Pharmaceutical Sciences (CNR Center for Drugs and Biological Products), University of Padua, Italy aut Veronese F. Department of Pharmaceutical Sciences (CNR Center for Drugs and Biological Products), University of Padua, Italy aut Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/10(2000-10-01), 643-654 0957-4530 11:10<643 2000 11 10856 https://doi.org/10.1023/A:1008970116308 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1008970116308 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Passi P. Dental School, Department of Dental Materials, University of Padua, Italy aut NATIONALLICENCE 700 1- Zadro A. Dental School, Department of Dental Materials, University of Padua, Italy aut NATIONALLICENCE 700 1- Marsilio F. Department of Pharmaceutical Sciences (CNR Center for Drugs and Biological Products), University of Padua, Italy aut NATIONALLICENCE 700 1- Lora S. Istituto di Fotochimica e Radiazioni d' Alta Energia del CNR, Legnaro, Padua, Italy aut NATIONALLICENCE 700 1- Caliceti P. Department of Pharmaceutical Sciences (CNR Center for Drugs and Biological Products), University of Padua, Italy aut NATIONALLICENCE 700 1- Veronese F. Department of Pharmaceutical Sciences (CNR Center for Drugs and Biological Products), University of Padua, Italy aut NATIONALLICENCE 773 0- Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/10(2000-10-01), 643-654 0957-4530 11:10<643 2000 11 10856 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer