caa a22 4500 475782860 CHVBK 20180406123649.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1023/A:1008920326988 doi (NATIONALLICENCE)springer-10.1023/A:1008920326988 Hydrolytic degradation of PCL/PEO copolymers in alkaline media [Elektronische Daten] [S. Li, X. Chen, R. Gross, S. Mccarthy] PCL/PEO copolymers with different compositions were obtained from ring opening polymerization of ε-caprolactone in the presence of ethylene oxide and characterized by various analytical techniques. Data collected from DSC and X-ray diffractometry suggested that the copolymer chains possess a blocky structure, leading to both PCL and PEO-type crystalline structures. Hydrolytic degradation of these copolymers was carried out in a pH=10.6 carbonate buffer solution at 37 °C. Comparison was made with a PCL homopolymer and a PCL/PEG blend which had the same gross composition as one of the copolymers. The results showed that the presence of PEO sequences considerably enhanced the hydrophilicity of the copolymers as compared with PCL homopolymer. Nevertheless, the degradability of PCL chains was not enhanced due to the phase separation between the two components. These materials should be of great interest for biomedical uses such as matrices for sustained drug delivery because of the presence of both hydrophilic and hydrophobic microdomains. ©2000 Kluwer Academic Publishers Kluwer Academic Publishers, 2000 Li S. Department of Plastics Engineering, University of Massachusetts, 1 University Avenue, 01851, Lowell, MA, USA aut Chen X. Department of Chemistry, University of Massachusetts, 1 University Avenue, 01851, Lowell, MA, USA aut Gross R. Department of Chemistry, University of Massachusetts, 1 University Avenue, 01851, Lowell, MA, USA aut Mccarthy S. Department of Plastics Engineering, University of Massachusetts, 1 University Avenue, 01851, Lowell, MA, USA aut Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/4(2000-04-01), 227-233 0957-4530 11:4<227 2000 11 10856 https://doi.org/10.1023/A:1008920326988 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1008920326988 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Li S. Department of Plastics Engineering, University of Massachusetts, 1 University Avenue, 01851, Lowell, MA, USA aut NATIONALLICENCE 700 1- Chen X. Department of Chemistry, University of Massachusetts, 1 University Avenue, 01851, Lowell, MA, USA aut NATIONALLICENCE 700 1- Gross R. Department of Chemistry, University of Massachusetts, 1 University Avenue, 01851, Lowell, MA, USA aut NATIONALLICENCE 700 1- Mccarthy S. Department of Plastics Engineering, University of Massachusetts, 1 University Avenue, 01851, Lowell, MA, USA aut NATIONALLICENCE 773 0- Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/4(2000-04-01), 227-233 0957-4530 11:4<227 2000 11 10856 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer