caa a22 4500 475782925 CHVBK 20180406123649.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1023/A:1008980629714 doi (NATIONALLICENCE)springer-10.1023/A:1008980629714 Cellulose-based hydrogels as body water retainers [Elektronische Daten] [A. Sannino, A. Esposito, L. Nicolais, M. Del Nobile, A. Giovane, C. Balestrieri, R. Esposito, M. Agresti] In this work the possibility of using hydrogels as body water retainers for a therapeutic aid in pathologies such as oedemas of various origins was explored. For such a purpose, the material requires a good compatibility and a controlled swelling capacity without altering the body electrolyte homeostasis. The hydrogel was designed to meet the swelling requirements with the physiological constraints and its biocompatibility was assessed either in vitro or in vivo. Absorption tests were performed in order to define the swelling behavior by varying the pH and ion content of the external solution. The hydrogel swelling capacity was assessed in the presence of various solvents, in order to evaluate its absorption capacity in solutions similar to biological fluids. In addition, the capacity of the gel to modify electrolyte homeostasis by adsorbing ions such as calcium, potassium and sodium was tested. In order to assess the gel biocompatibility after contact of the hydrogel with intestinal cells, arachidonic acid relase was determined. No significant intracellular increase of free arachidonic acid was found in the cells after up to 2 h of contact with the gel. The results suggest that, as far as brief periods are concerned, the gel does not cause an inflammatory response in intestinal cells. ©2000 Kluwer Academic Publishers Kluwer Academic Publishers, 2000 Sannino A. Department of Materials and Production Engineering, University of Naples "Federico II”, Piazzale Tecchio, 80-80125, Naples, Italy aut Esposito A. Department of Materials and Production Engineering, University of Naples "Federico II”, Piazzale Tecchio, 80-80125, Naples, Italy aut Nicolais L. Department of Materials and Production Engineering, University of Naples "Federico II”, Piazzale Tecchio, 80-80125, Naples, Italy aut Del Nobile M. National Research Council, Institute of Composite Materials Technology, Piazzale Tecchio, 80-80125, Naples, Italy aut Giovane A. Department of Biochemistry and Biophysics, Second University of Naples, Via Costantinopoli, 16 80138, Naples, Italy aut Balestrieri C. Department of Biochemistry and Biophysics, Second University of Naples, Via Costantinopoli, 16 80138, Naples, Italy aut Esposito R. Division of Clinical Nutrition, Institute of Surgical Anatomy, Piazza Miraglia, 80138, Naples, Italy aut Agresti M. Institute of Surgical Senology, Piazza Miraglia, 80138, Naples, Italy aut Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/4(2000-04-01), 247-253 0957-4530 11:4<247 2000 11 10856 https://doi.org/10.1023/A:1008980629714 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1008980629714 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sannino A. Department of Materials and Production Engineering, University of Naples "Federico II”, Piazzale Tecchio, 80-80125, Naples, Italy aut NATIONALLICENCE 700 1- Esposito A. Department of Materials and Production Engineering, University of Naples "Federico II”, Piazzale Tecchio, 80-80125, Naples, Italy aut NATIONALLICENCE 700 1- Nicolais L. Department of Materials and Production Engineering, University of Naples "Federico II”, Piazzale Tecchio, 80-80125, Naples, Italy aut NATIONALLICENCE 700 1- Del Nobile M. National Research Council, Institute of Composite Materials Technology, Piazzale Tecchio, 80-80125, Naples, Italy aut NATIONALLICENCE 700 1- Giovane A. Department of Biochemistry and Biophysics, Second University of Naples, Via Costantinopoli, 16 80138, Naples, Italy aut NATIONALLICENCE 700 1- Balestrieri C. Department of Biochemistry and Biophysics, Second University of Naples, Via Costantinopoli, 16 80138, Naples, Italy aut NATIONALLICENCE 700 1- Esposito R. Division of Clinical Nutrition, Institute of Surgical Anatomy, Piazza Miraglia, 80138, Naples, Italy aut NATIONALLICENCE 700 1- Agresti M. Institute of Surgical Senology, Piazza Miraglia, 80138, Naples, Italy aut NATIONALLICENCE 773 0- Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/4(2000-04-01), 247-253 0957-4530 11:4<247 2000 11 10856 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer