caa a22 4500 475782933 CHVBK 20180406123649.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1023/A:1008936830622 doi (NATIONALLICENCE)springer-10.1023/A:1008936830622 Effect of particles and interface conditions on fibrous tissue interposition between bone and implant. A particle challenge model in rabbit [Elektronische Daten] [H. Ohashi, A. Kobayashi, Y. Kadoya, Y. Yamano, H. Oonishi, H. Iwaki] Interposed fibrous tissue at bone-implant interfaces was quantitatively measured in the presence or absence of polyethylene (PE) or alumina particles. Three different conditions of the interface were designed by implanting a pre-polymerized polymethylmethacrylate (PMMA) plug (plug group), a doughy PMMA (injection group) and a hydroxyapatite (HA) plug (HA group) in the hole drilled at the intercondylar notch of rabbit knees. PE (170±18 μm) or alumina particles (88±26 μm) were repeatedly administered into the knee joints at one month intervals (six times). All animals were sacrificed seven months after the implantation. The bone-implant interface was histomorphometrically examined using undecalcified ground sections. In the plug group, the PE particles significantly increased the extent of the interposed fibrous tissue (p < 0.05), while the alumina particles showed no effect. In contrast, both particles showed no significant effects in the injection and the HA groups. These results indicate that both particle characteristics and conditions of the bone-implant interface affected particle-induced fibrous tissue interposition. The loose PMMA plug with PE particles induced the greatest amount of fibrous tissue interposition. ©2000 Kluwer Academic Publishers Kluwer Academic Publishers, 2000 Ohashi H. Department of Orthopaedic Surgery, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, 545-8585, Osaka, Japan aut Kobayashi A. Department of Orthopaedic Surgery, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, 545-8585, Osaka, Japan aut Kadoya Y. Department of Orthopaedic Surgery, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, 545-8585, Osaka, Japan aut Yamano Y. Department of Orthopaedic Surgery, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, 545-8585, Osaka, Japan aut Oonishi H. Department of Orthopaedic Surgery, Osaka-Minami National Hospital, 2-1 Kidohigashicho, 586-0000, Kawachinagano, Japan aut Iwaki H. Department of Orthopaedic Surgery, Osaka-Minami National Hospital, 2-1 Kidohigashicho, 586-0000, Kawachinagano, Japan aut Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/4(2000-04-01), 255-259 0957-4530 11:4<255 2000 11 10856 https://doi.org/10.1023/A:1008936830622 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1008936830622 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ohashi H. Department of Orthopaedic Surgery, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, 545-8585, Osaka, Japan aut NATIONALLICENCE 700 1- Kobayashi A. Department of Orthopaedic Surgery, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, 545-8585, Osaka, Japan aut NATIONALLICENCE 700 1- Kadoya Y. Department of Orthopaedic Surgery, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, 545-8585, Osaka, Japan aut NATIONALLICENCE 700 1- Yamano Y. Department of Orthopaedic Surgery, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, 545-8585, Osaka, Japan aut NATIONALLICENCE 700 1- Oonishi H. Department of Orthopaedic Surgery, Osaka-Minami National Hospital, 2-1 Kidohigashicho, 586-0000, Kawachinagano, Japan aut NATIONALLICENCE 700 1- Iwaki H. Department of Orthopaedic Surgery, Osaka-Minami National Hospital, 2-1 Kidohigashicho, 586-0000, Kawachinagano, Japan aut NATIONALLICENCE 773 0- Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/4(2000-04-01), 255-259 0957-4530 11:4<255 2000 11 10856 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer