caa a22 4500 475783093 CHVBK 20180406123650.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1023/A:1008913501297 doi (NATIONALLICENCE)springer-10.1023/A:1008913501297 Theoretical relationship between maximum pore size and toughness in experimental inflammatory arthritis [Elektronische Daten] [M. Pysklywec, E. Bogoch] Rheumatoid arthritis increases the risk of fracture. In an animal model of inflammatory arthritis, femoral diaphysis had a decreased toughness as well as increased cortical porosity, when compared to normal bone. Based on the hypothesis that stress concentration from the large porous defects reduces the ability of the cortical bone to resist failure, this work determined if the changes observed in porosity could explain the changes observed in toughness. Using theoretical relationships of the stress concentration and stress states, a model of the observed conditions was considered. A relationship was developed that indicated the relative difference in toughness between normal and arthritic specimens as a function of pore size. Results indicated that the increase in cortical pore size could theoretically reduce toughness by 55%. This decrease compares with the experimentally observed drop in toughness of 61%. Furthermore, the critical parameter for fracture in this situation is the ratio of pore diameter to cortical thickness. Efforts to reduce cortical porosity seen in inflammatory arthritis would be effective in enhancing the toughness of bone and may reduce morbidity in a human population. ©2000 Kluwer Academic Publishers Kluwer Academic Publishers, 2000 Pysklywec M. Orthopaedic Research Laboratory, University of Toronto, St Michael's Hospital, 160 Wellesley St. E., M4Y 1J3, Toronto, Ontario, Canada aut Bogoch E. University of Toronto, St Michael's Hospital, 160 Wellesley St. E., M4Y 1J3, Toronto, Ontario, Canada aut Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/5(2000-05-01), 313-318 0957-4530 11:5<313 2000 11 10856 https://doi.org/10.1023/A:1008913501297 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1008913501297 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pysklywec M. Orthopaedic Research Laboratory, University of Toronto, St Michael's Hospital, 160 Wellesley St. E., M4Y 1J3, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Bogoch E. University of Toronto, St Michael's Hospital, 160 Wellesley St. E., M4Y 1J3, Toronto, Ontario, Canada aut NATIONALLICENCE 773 0- Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/5(2000-05-01), 313-318 0957-4530 11:5<313 2000 11 10856 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer