caa a22 4500 475783166 CHVBK 20180406123650.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1023/A:1008980631780 doi (NATIONALLICENCE)springer-10.1023/A:1008980631780 Improvement of titanium alloy for biomedical applications by nitriding and carbonitriding processes under glow discharge conditions [Elektronische Daten] [E. Czarnowska, T. Wierzchon´, A. Maranda-Niedbala, E. Karczmarewicz] Although titanium alloys are used in medicine, they present low wear resistance. In this paper we present the results of studies on surface layers produced by nitriding at three different temperatures, and by carbonitriding under glow discharge conditions in order to improve wear resistance, hardness, and to modulate microstructure and chemical composition of surface layers. A cell culture model using human fibroblasts was chosen to study the effect of such treatments on the cytocompatibility of these materials. The results showed that nitrided and carbonitrided surface layers were cytocompatible. Modulation of surface microstructure by temperature in the nitriding process and chemical composition of surface layers by carbonitriding led to differences in cellular behaviour. Cell proliferation appeared to be slightly reduced from the 6th day of culture on nitrided surfaces produced at 730 °C and 1000 °C, however after 12 days of culture, the best growth was on surface layers produced at 850 °C. The best viability was observed on the carbonitrided layer. The orientation and shape of the cells corresponded to surface topography. Nitriding and carbonitriding under glow discharge conditions may constitute interesting techniques allowing the formation of surface layers on parts with sophisticated shapes. They may also permit modulating surface topography in a way improving the features of titanium alloys for various applications in medicine. Kluwer Academic Publishers, 2000 Czarnowska E. Pathology Department, The Children's Memorial Health Institute, Warsaw, Poland aut Wierzchon´ T. Faculty of Materials Science and Engineering, Warsaw University of Technology, Warsaw, Poland aut Maranda-Niedbala A. Faculty of Materials Science and Engineering, Warsaw University of Technology, Warsaw, Poland aut Karczmarewicz E. Experimental Medicine Department, The Children's Memorial Health Institute, Warsaw, Poland aut Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/2(2000-02-01), 73-81 0957-4530 11:2<73 2000 11 10856 https://doi.org/10.1023/A:1008980631780 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1008980631780 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Czarnowska E. Pathology Department, The Children's Memorial Health Institute, Warsaw, Poland aut NATIONALLICENCE 700 1- Wierzchon´ T. Faculty of Materials Science and Engineering, Warsaw University of Technology, Warsaw, Poland aut NATIONALLICENCE 700 1- Maranda-Niedbala A. Faculty of Materials Science and Engineering, Warsaw University of Technology, Warsaw, Poland aut NATIONALLICENCE 700 1- Karczmarewicz E. Experimental Medicine Department, The Children's Memorial Health Institute, Warsaw, Poland aut NATIONALLICENCE 773 0- Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/2(2000-02-01), 73-81 0957-4530 11:2<73 2000 11 10856 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer