caa a22 4500 475783204 CHVBK 20180406123650.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1023/A:1008940916759 doi (NATIONALLICENCE)springer-10.1023/A:1008940916759 Litvin A. Laboratory for the Study of Skeletal Disorders and Rehabilitation, Department of Orthopaedic Surgery, Harvard Medical School, Children's Hospital, 300 Longwood Ave, 02115, Boston, MA, USA aut Surface design of orthopaedic drug delivery implants: X-ray photoelectron spectroscopy of bone-derived apatites [Elektronische Daten] [A. Litvin] Incorporation of foreign ions onto a biomineral surface as well as removal from it of native (physiological) ions during deproteination procedures, are discussed in view of surface design of orthopaedic implants serving as drug delivery carriers. Surface properties of bone-derived apatites, purified at low temperature in non-aqueous medium, and of several commercial samples are examined via XPS technique. It has been demonstrated that, in spite of the fact that the initial bone demineralized matrix is derived from the same bovine bone, different deproteination procedures lead to different surface properties. Correlation between carbon 1s deconvoluted peak and the percentage of the residual organic fraction on the bone-derived apatites' surface at different stages of purification has been established. Kluwer Academic Publishers, 2000 Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/2(2000-02-01), 91-94 0957-4530 11:2<91 2000 11 10856 https://doi.org/10.1023/A:1008940916759 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1008940916759 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Litvin A. Laboratory for the Study of Skeletal Disorders and Rehabilitation, Department of Orthopaedic Surgery, Harvard Medical School, Children's Hospital, 300 Longwood Ave, 02115, Boston, MA, USA aut NATIONALLICENCE 773 0- Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/2(2000-02-01), 91-94 0957-4530 11:2<91 2000 11 10856 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer