caa a22 4500 475783212 CHVBK 20180406123650.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1023/A:1008936832689 doi (NATIONALLICENCE)springer-10.1023/A:1008936832689 Healing of titanium implants in onlay bone grafts: an experimental rabbit model [Elektronische Daten] [S. Mohammadi, L. Rasmusson, L. Go¨ransson, L. Sennerby, P. Thomsen, K. Kahnberg] An experimental rabbit bone graft model for the study of bone formation and remodeling around titanium implants is described. A 2.5-cm long radius bone segment served as an onlay graft. Two commercially pure (c.p.) titanium implants were inserted into the bone graft prior to fixation to the inferior border of the mandibular base with osteosynthesis titanium screws. Each animal was operated twice, allowing follow-up periods of 6 weeks on one side and 6 months on the contralateral side. In order to study bone remodeling by means of fluoroscopy the animals received single injections of tetracyclin and alizarine complexone 2 weeks and 1 week, respectively, prior to sacrifice by perfusion fixation with glutaraldehyde. The bone and implants were excized en bloc, postfixed and embedded in plastic resin. Stained and unstained thin ground sections as well as microradiographed thick sections were produced for light microscopic morphometry and fluoroscopy. After 6 weeks, osteoclastic/osteoblastic activity was primarily observed in the graft-recipient contact area and in the intracortical compartment of the graft bone. New bone formation observed on the implant surface originated from the recipient site. The bone formation was evident also in the implant-graft interface. At 6 weeks the average bone fill of the implant threads was 28.4% which increased to 36.4% after 6 months as measured by morphometry. An average of 17.6% bony contact was measured after 6 weeks which increased to 29.7% 6 months after surgery. The graft bone had reduced in size from an average of 39.5% after 6 weeks down to 24.8% after 6 months (P < 0.05). It is concluded that the described experimental model can serve as a useful method for the study of implant healing in onlay grafts. Kluwer Academic Publishers, 2000 Mohammadi S. Institute of Anatomy and Cell Biology, Sweden aut Rasmusson L. Department of Biomaterials/Handicap Research, Institute for Surgical Sciences, Sweden aut Go¨ransson L. aut Sennerby L. Department of Biomaterials/Handicap Research, Institute for Surgical Sciences, Department of Oral and Maxillofacial Surgery, Go¨teborg University, Sweden aut Thomsen P. Institute of Anatomy and Cell Biology, Sweden aut Kahnberg K. Department of Oral and Maxillofacial Surgery, Go¨teborg University, Sweden aut Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/2(2000-02-01), 83-89 0957-4530 11:2<83 2000 11 10856 https://doi.org/10.1023/A:1008936832689 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1008936832689 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mohammadi S. Institute of Anatomy and Cell Biology, Sweden aut NATIONALLICENCE 700 1- Rasmusson L. Department of Biomaterials/Handicap Research, Institute for Surgical Sciences, Sweden aut NATIONALLICENCE 700 1- Go¨ransson L. aut NATIONALLICENCE 700 1- Sennerby L. Department of Biomaterials/Handicap Research, Institute for Surgical Sciences, Department of Oral and Maxillofacial Surgery, Go¨teborg University, Sweden aut NATIONALLICENCE 700 1- Thomsen P. Institute of Anatomy and Cell Biology, Sweden aut NATIONALLICENCE 700 1- Kahnberg K. Department of Oral and Maxillofacial Surgery, Go¨teborg University, Sweden aut NATIONALLICENCE 773 0- Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/2(2000-02-01), 83-89 0957-4530 11:2<83 2000 11 10856 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer