caa a22 4500 475783220 CHVBK 20180406123650.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1023/A:1008901302646 doi (NATIONALLICENCE)springer-10.1023/A:1008901302646 Quantitative analysis of polyethylene wear debris, wear rate and head damage in retrieved Charnley hip prostheses [Elektronische Daten] [J. Tipper, E. Ingham, J. Hailey, A. Besong, J. Fisher, B. Wroblewski, M. Stone] Submicrometer- and micrometer-sized ultra-high molecular weight polyethylene (UHMWPE) wear particles have been associated with osteolysis and failure of total artificial joints. Previous studies have isolated predominantly submicrometer-sized particles at the expense of larger particles (>10 μm). This study aimed to isolate and characterize quantitatively all sizes of UHMWPE wear particles generated in 18 Charnley hip prostheses. In addition, to analyze the wear debris with respect to the total volumetric wear of the cup and damage to the femoral head. Particle size distributions ranged from 0.1 to ->1000 μm. A significant proportion (3-82%) of the mass of the wear debris isolated was>10 μm. The mode of the frequency distribution of the particles was in the range 0.1-0.5 μm for all patients. However, analysis of the mass of wear debris as a function of its size allowed differentiation of the wear debris from different patients. Femoral head damage was associated with high volumetric wear and increased numbers of biologically active submicrometer-sized particles. Kluwer Academic Publishers, 2000 Tipper J. Departments of Microbiology, University of Leeds, LS2 9JT, Leeds, UK aut Ingham E. Departments of Microbiology, University of Leeds, LS2 9JT, Leeds, UK aut Hailey J. Departments of Microbiology and *Mechanical Engineering, University of Leeds, LS2 9JT, Leeds, UK aut Besong A. Departments of Microbiology and *Mechanical Engineering, University of Leeds, LS2 9JT, Leeds, UK aut Fisher J. Departments of Microbiology and *Mechanical Engineering, University of Leeds, LS2 9JT, Leeds, UK aut Wroblewski B. Centre for Hip Surgery, Wrightington Hospital, Wigan, UK aut Stone M. Department of Orthopaedic Surgery, The General Infirmary, LS1 3EX, Leeds, UK aut Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/2(2000-02-01), 117-124 0957-4530 11:2<117 2000 11 10856 https://doi.org/10.1023/A:1008901302646 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1008901302646 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tipper J. Departments of Microbiology, University of Leeds, LS2 9JT, Leeds, UK aut NATIONALLICENCE 700 1- Ingham E. Departments of Microbiology, University of Leeds, LS2 9JT, Leeds, UK aut NATIONALLICENCE 700 1- Hailey J. Departments of Microbiology and *Mechanical Engineering, University of Leeds, LS2 9JT, Leeds, UK aut NATIONALLICENCE 700 1- Besong A. Departments of Microbiology and *Mechanical Engineering, University of Leeds, LS2 9JT, Leeds, UK aut NATIONALLICENCE 700 1- Fisher J. Departments of Microbiology and *Mechanical Engineering, University of Leeds, LS2 9JT, Leeds, UK aut NATIONALLICENCE 700 1- Wroblewski B. Centre for Hip Surgery, Wrightington Hospital, Wigan, UK aut NATIONALLICENCE 700 1- Stone M. Department of Orthopaedic Surgery, The General Infirmary, LS1 3EX, Leeds, UK aut NATIONALLICENCE 773 0- Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/2(2000-02-01), 117-124 0957-4530 11:2<117 2000 11 10856 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer