caa a22 4500 475783298 CHVBK 20180406123650.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1023/A:1008959325997 doi (NATIONALLICENCE)springer-10.1023/A:1008959325997 Effect of skin-penetrating enhancers on the thermophysical properties of cholesteryl oleyl carbonate embedded in a thermo-responsive membrane [Elektronische Daten] [Shan-Yang Lin, Mei-Jane Li, Hsiu-Li Lin] The effect of skin-penetrating enhancers such as propylene glycol (PG), Azone and ethanol on the thermophysical properties of cholesteryl oleyl carbonate (COC) was investigated using differential scanning colorimetry (DSC) and microscopic Fourier-transform infrared (FT-IR) spectroscopy. The results indicate that PG did not influence the DSC thermograms and IR spectra of COC in the different ratios of COC and PG mixture; whereas Azone interacted with COC not only to lower the semectic-cholesteric phase transition temperature of COC but also to induce a new IR spectral peak at cm-11653cm-1 which shifted from the carbonyl stretching band (cm-11636 cm-1) of Azone. Ethanol did not interact with COC, but it influenced the IR spectral peak intensity of COC at cm-11253cm-1. The peak intensity at cm-11253cm-1 gradually rose with the time of ethanol evaporation and was similar to that of the temperature effect. The solubility parameter was also used to explain the miscibility and interaction between COC and PG, Azone or ethanol. © 2000 Kluwer Academic Publishers Kluwer Academic Publishers, 2000 Lin Shan-Yang Biopharmaceutics Laboratory, Department of Medical Research and Education, Veterans General Hospital-Taipei, Taipei, Taiwan aut Li Mei-Jane Biopharmaceutics Laboratory, Department of Medical Research and Education, Veterans General Hospital-Taipei, Taipei, Taiwan aut Lin Hsiu-Li Biopharmaceutics Laboratory, Department of Medical Research and Education, Veterans General Hospital-Taipei, Taipei, Taiwan aut Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/11(2000-11-01), 701-704 0957-4530 11:11<701 2000 11 10856 https://doi.org/10.1023/A:1008959325997 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1008959325997 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lin Shan-Yang Biopharmaceutics Laboratory, Department of Medical Research and Education, Veterans General Hospital-Taipei, Taipei, Taiwan aut NATIONALLICENCE 700 1- Li Mei-Jane Biopharmaceutics Laboratory, Department of Medical Research and Education, Veterans General Hospital-Taipei, Taipei, Taiwan aut NATIONALLICENCE 700 1- Lin Hsiu-Li Biopharmaceutics Laboratory, Department of Medical Research and Education, Veterans General Hospital-Taipei, Taipei, Taiwan aut NATIONALLICENCE 773 0- Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/11(2000-11-01), 701-704 0957-4530 11:11<701 2000 11 10856 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer