caa a22 4500 475783301 CHVBK 20180406123650.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1023/A:1008971611885 doi (NATIONALLICENCE)springer-10.1023/A:1008971611885 Bone healing in porous implants: a histological and histometrical comparative study on sheep [Elektronische Daten] [Y. Liu, J. Schoenaers, K. Groot, J. Wijn, E. Schepers] Tissue integration in four types of porous implant materials (Interpore 200® or Corallin hydroxyapatite, hydroxyapatite blocks, hydroxyapatite granules and polymethylmethacrylate) was evaluated in vivo. Porous blocks measuring 20 mm × 10 mm × 8 mm were implanted in mandibles and iliac crests of sheep. Bone healing in porous blocks was studied at 2 and 6 months after implantation. The behavior of the material itself was also analyzed. Histological and histomorphometrical analysis revealed bone healing depending upon healing time and material. On the basis of analysis of variance, differences in amounts of bone ingrowth at 2 and 6 months were statistically significant (p = 0.0039 in mandible; p = 0.0351 in iliac crest). The longer the time span, the more mineralized tissues were observed in the specimen. Our data confirmed that hydroxyapatite has osteoconductive capacities. Porous PMMA was found to be biocompatible, but it showed less bonegrowth within the pores. Interpore 200®, which had the highest surface to volume ratio was found to display the highest level of osseointegration and biodegradation. © 2000 Kluwer Academic Publishers Kluwer Academic Publishers, 2000 Liu Y. Department of Oral and Maxillofacial Surgery, Catholic University of Leuven, Capucijnenvoer 7, 3000, Leuven, Belgium aut Schoenaers J. Department of Oral and Maxillofacial Surgery, Catholic University of Leuven, Capucijnenvoer 7, 3000, Leuven, Belgium aut Groot K. Biomaterials Research Group, Faculty of Medicine, University of Leiden, Prof. Bronkhorstlaan 10, 3723 MB, Bilthoven, The Netherlands aut Wijn J. Biomaterials Research Group, Faculty of Medicine, University of Leiden, Prof. Bronkhorstlaan 10, 3723 MB, Bilthoven, The Netherlands aut Schepers E. Department of Prosthetic Dentistry, Catholic University of Leuven, Capucijnenvoer 7, 3000, Leuven, Belgium aut Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/11(2000-11-01), 711-717 0957-4530 11:11<711 2000 11 10856 https://doi.org/10.1023/A:1008971611885 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1008971611885 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liu Y. Department of Oral and Maxillofacial Surgery, Catholic University of Leuven, Capucijnenvoer 7, 3000, Leuven, Belgium aut NATIONALLICENCE 700 1- Schoenaers J. Department of Oral and Maxillofacial Surgery, Catholic University of Leuven, Capucijnenvoer 7, 3000, Leuven, Belgium aut NATIONALLICENCE 700 1- Groot K. Biomaterials Research Group, Faculty of Medicine, University of Leiden, Prof. Bronkhorstlaan 10, 3723 MB, Bilthoven, The Netherlands aut NATIONALLICENCE 700 1- Wijn J. Biomaterials Research Group, Faculty of Medicine, University of Leiden, Prof. Bronkhorstlaan 10, 3723 MB, Bilthoven, The Netherlands aut NATIONALLICENCE 700 1- Schepers E. Department of Prosthetic Dentistry, Catholic University of Leuven, Capucijnenvoer 7, 3000, Leuven, Belgium aut NATIONALLICENCE 773 0- Journal of Materials Science: Materials in Medicine Kluwer Academic Publishers 11/11(2000-11-01), 711-717 0957-4530 11:11<711 2000 11 10856 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer