caa a22 4500 47578359X CHVBK 20180406123651.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1023/A:1008114831862 doi (NATIONALLICENCE)springer-10.1023/A:1008114831862 Preliminary study of the in vitro antiproliferative effect of a hydroethanolic extract from the subtropical seaweed Turbinaria ornata (Turner) J. Agardh on a human non-small-cell bronchopulmonary carcinoma line (NSCLC-N6) [Elektronische Daten] [E. Deslandes, P. Pondaven, T. Auperin, C. Roussakis C, J. Guézennec, V. Stiger, C. Payri] An unusual sulfated fucan-like polysaccharidecontaining aminosugar constituent was isolated fromthe brown Fucales, Turbinaria ornata. Itsantiproliferative effect on asynchronous cells of ahuman non-small-cell bronchopulmonary carcinoma line(NSCLC-N6) was studied in vitro. The kinetics ofcell growth further to the continuous exposure ofcells to T. ornata extract was investigated andthe changes in the cell cycle were observed usingflow-cytometry. Cell growth appeared to be inhibitedin the G1 phase. Altogether our observations suggesta triggering of the terminal differentiation ofcancerous cells by this fucan-like polysaccharide. Kluwer Academic Publishers, 2000 fucan-like polysaccharide nationallicence amino-sugar nationallicence bronchopulmonary carcinoma nationallicence antiproliferative effect nationallicence cell cycle nationallicence brown seaweed nationallicence Turbinaria ornata nationallicence Deslandes E. LEBAM-IUEM, Université de Bretagne Occidentale, place Nicolas Copernic, 29280, Plouzané, France aut Pondaven P. Faculté des Sciences, ISOMer, 2 rue de la Houssinière, F44322, Nantes, Brittany, France aut Auperin T. Department of Biological Chemistry and Molecular Pharmacology, 02115, Boston, Massachussetts, USA aut Roussakis C C. Faculté des Sciences, ISOMer, 2 rue de la Houssinière, F44322, Nantes, Brittany, France aut Guézennec J. IFREMER-DRV/EP/LBMH, 29280, Plouzané, France aut Stiger V. LEM, Université Française du Pacifique, Tahiti-P.F aut Payri C. LEM, Université Française du Pacifique, Tahiti-P.F aut Journal of Applied Phycology Kluwer Academic Publishers 12/3-5(2000-10-01), 257-262 0921-8971 12:3-5<257 2000 12 10811 https://doi.org/10.1023/A:1008114831862 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1008114831862 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Deslandes E. LEBAM-IUEM, Université de Bretagne Occidentale, place Nicolas Copernic, 29280, Plouzané, France aut NATIONALLICENCE 700 1- Pondaven P. Faculté des Sciences, ISOMer, 2 rue de la Houssinière, F44322, Nantes, Brittany, France aut NATIONALLICENCE 700 1- Auperin T. Department of Biological Chemistry and Molecular Pharmacology, 02115, Boston, Massachussetts, USA aut NATIONALLICENCE 700 1- Roussakis C C. Faculté des Sciences, ISOMer, 2 rue de la Houssinière, F44322, Nantes, Brittany, France aut NATIONALLICENCE 700 1- Guézennec J. IFREMER-DRV/EP/LBMH, 29280, Plouzané, France aut NATIONALLICENCE 700 1- Stiger V. LEM, Université Française du Pacifique, Tahiti-P.F aut NATIONALLICENCE 700 1- Payri C. LEM, Université Française du Pacifique, Tahiti-P.F aut NATIONALLICENCE 773 0- Journal of Applied Phycology Kluwer Academic Publishers 12/3-5(2000-10-01), 257-262 0921-8971 12:3-5<257 2000 12 10811 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer