caa a22 4500 475783883 CHVBK 20180406123652.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1023/A:1008170007044 doi (NATIONALLICENCE)springer-10.1023/A:1008170007044 Allelopathic actions of the alkaloid 12- epi- hapalindole E isonitrile and calothrixin A from cyanobacteria of the genera Fischerella and Calothrix [Elektronische Daten] [Nga Thanh Doan, Rodney Rickards, Jennifer Rothschild, Geoffrey Smith] The alkaloids 12-epi-hapalindole E isonitrile,isolated from the cyanobacterium Fischerellasp., and the indolophenanthridine calothrixin A, fromCalothrix sp., were characterized in terms oftheir ability to kill several organisms and celltypes, and their biochemical modes of action. Bothcompounds inhibited RNA synthesis, and consequentlyprotein synthesis, in Bacillus subtilis. Calothrixin A also inhibited DNA replication, thehapalindole having little effect on this process. Measurements of in vitro RNA synthesis confirmedthe in vivo results and suggested that bothcompounds inhibit RNA polymerase directly; the degreeof inhibition was independent of the DNAconcentration, but strongly dependent on thepolymerase concentration. Kluwer Academic Publishers, 2000 cyanobacteria nationallicence bioactive compounds nationallicence allelopathy nationallicence calothrixin nationallicence hapalindole nationallicence alkaloids nationallicence Fischerella nationallicence Calothrix nationallicence Thanh Doan Nga Division of Biochemistry and Molecular Biology, School of Life Sciences, Faculty of Science, Australia aut Rickards Rodney Research School of Chemistry, Institute of Advanced Studies, The Australian National University, Australia aut Rothschild Jennifer Research School of Chemistry, Institute of Advanced Studies, The Australian National University, Australia aut Smith Geoffrey Division of Biochemistry and Molecular Biology, School of Life Sciences, Faculty of Science, 0200, ACT, Australia aut Journal of Applied Phycology Kluwer Academic Publishers 12/3-5(2000-10-01), 409-416 0921-8971 12:3-5<409 2000 12 10811 https://doi.org/10.1023/A:1008170007044 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1008170007044 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Thanh Doan Nga Division of Biochemistry and Molecular Biology, School of Life Sciences, Faculty of Science, Australia aut NATIONALLICENCE 700 1- Rickards Rodney Research School of Chemistry, Institute of Advanced Studies, The Australian National University, Australia aut NATIONALLICENCE 700 1- Rothschild Jennifer Research School of Chemistry, Institute of Advanced Studies, The Australian National University, Australia aut NATIONALLICENCE 700 1- Smith Geoffrey Division of Biochemistry and Molecular Biology, School of Life Sciences, Faculty of Science, 0200, ACT, Australia aut NATIONALLICENCE 773 0- Journal of Applied Phycology Kluwer Academic Publishers 12/3-5(2000-10-01), 409-416 0921-8971 12:3-5<409 2000 12 10811 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer