caa a22 4500 475783980 CHVBK 20180406123652.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1023/A:1008140403621 doi (NATIONALLICENCE)springer-10.1023/A:1008140403621 Skulberg Olav Norwegian Institute for Water Research, N-0411, Oslo, Norway aut Microalgae as a source of bioactive molecules - experience from cyanophyte research [Elektronische Daten] [Olav Skulberg] Detrimental and beneficial properties of prokaryoticand eukaryotic microalgae may be qualifications givingthem posibillities for their biotechnologicalutilization. Phycotoxins and related products mayserve as material for useful drugs. Cyanotoxins arean example. Bioassay screening methods are used todetect specific biological activity (e.g. antibioticeffects). A study demonstrating antibacterialproperties among cyanophytes showed that these effectswere caused by substances produced by both toxigenicand non-toxigenic strains. Differences inbiosynthetic activity are influenced by the type ofclones and by the culture conditions (genetic andbiochemical variation). Experience of recentscreening (1997-1998) of compounds from cyanophytes -including 25 species from 14 genera - display thediscovery of more than 30 different antibioticsubstances. The further isolation of newpharmaceuticals from natural resources is becomingdifficult, if not uncommon species of producerorganisms are taken into consideration. Kluwer Academic Publishers, 2000 secondary metabolites nationallicence cyanophytes nationallicence antibiotic activity nationallicence screening nationallicence new compounds nationallicence prospectives nationallicence Journal of Applied Phycology Kluwer Academic Publishers 12/3-5(2000-10-01), 341-348 0921-8971 12:3-5<341 2000 12 10811 https://doi.org/10.1023/A:1008140403621 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1008140403621 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Skulberg Olav Norwegian Institute for Water Research, N-0411, Oslo, Norway aut NATIONALLICENCE 773 0- Journal of Applied Phycology Kluwer Academic Publishers 12/3-5(2000-10-01), 341-348 0921-8971 12:3-5<341 2000 12 10811 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer