caa a22 4500 475784235 CHVBK 20180406123653.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s004310051304 doi (NATIONALLICENCE)springer-10.1007/s004310051304 Apparent life-threatening events, facial dysmorphia and sleep-disordered breathing [Elektronische Daten] [Christian Guilleminault, Rafael Pelayo, Damien Leger, Pierre Philip] A standardized clinical evaluation and questionnaire was, beginning in 1985, applied to infants referred for an apparent life-threatening event (ALTE). All children who underwent this "core evaluation protocol” during a 10-year period were reviewed. Documentation of clinical complaints, symptoms and signs of sleep-disordered breathing, sleep/wake evaluation, systematic evaluation of the face and naso-oro-pharynx, nocturnal polygraphic recording, and systematic follow-up was conducted. A total of 346 infants had complete data sets, with a smaller group of 46 age-matched healthy infants as controls. A scorer blind to the clinical data analyzed the polygraphic investigation and divided the 346 referred into two groups. Group A, 42.6% of the population, included infants with no abnormal findings based on nocturnal polygraphic recording. These infants were no different from controls at initial evaluation and during follow-up. Group B, 57.4% of the population, included infants who had obstructive breathing during sleep which became more obvious over time. Two-thirds of these infants not only had clinical symptoms of sleep-disordered breathing but also had mild facial dysmorphia that could be seen clearly at 6 months of age. Conclusion A subgroup of infants with apparent life-threatening events present an indication of a sleep-disordered breathing syndrome which is associated with a mild dysmorphia. This mild facial dysmorphia needs to be recognized early to distinguish these infants from other infants with apparent life-threatening events and to initiate appropriate treatment. Springer-Verlag Berlin Heidelberg, 2000 Key words Infant nationallicence Sleep-disordered breathing nationallicence Apparent life-threatening event nationallicence Obstructive sleep apnea nationallicence Familial aggregate nationallicence AbbreviationsALTE apparent life-threatening event nationallicence Pes esophageal pressure nationallicence SIDS sudden infant death syndrome nationallicence Guilleminault Christian Stanford University Sleep Disorders Center, 401 Quarry Road, Suite 330, Stanford, CA 94305, USA e-mail: cguil@leland.stanford.edu; Tel.: +1-650-7236601; Fax: +1-650-7258910, US aut Pelayo Rafael Stanford University Sleep Disorders Center, 401 Quarry Road, Suite 330, Stanford, CA 94305, USA e-mail: cguil@leland.stanford.edu; Tel.: +1-650-7236601; Fax: +1-650-7258910, US aut Leger Damien Stanford University Sleep Disorders Center, 401 Quarry Road, Suite 330, Stanford, CA 94305, USA e-mail: cguil@leland.stanford.edu; Tel.: +1-650-7236601; Fax: +1-650-7258910, US aut Philip Pierre Stanford University Sleep Disorders Center, 401 Quarry Road, Suite 330, Stanford, CA 94305, USA e-mail: cguil@leland.stanford.edu; Tel.: +1-650-7236601; Fax: +1-650-7258910, US aut https://doi.org/10.1007/s004310051304 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004310051304 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Guilleminault Christian Stanford University Sleep Disorders Center, 401 Quarry Road, Suite 330, Stanford, CA 94305, USA e-mail: cguil@leland.stanford.edu; Tel.: +1-650-7236601; Fax: +1-650-7258910, US aut NATIONALLICENCE 700 1- Pelayo Rafael Stanford University Sleep Disorders Center, 401 Quarry Road, Suite 330, Stanford, CA 94305, USA e-mail: cguil@leland.stanford.edu; Tel.: +1-650-7236601; Fax: +1-650-7258910, US aut NATIONALLICENCE 700 1- Leger Damien Stanford University Sleep Disorders Center, 401 Quarry Road, Suite 330, Stanford, CA 94305, USA e-mail: cguil@leland.stanford.edu; Tel.: +1-650-7236601; Fax: +1-650-7258910, US aut NATIONALLICENCE 700 1- Philip Pierre Stanford University Sleep Disorders Center, 401 Quarry Road, Suite 330, Stanford, CA 94305, USA e-mail: cguil@leland.stanford.edu; Tel.: +1-650-7236601; Fax: +1-650-7258910, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer