caa a22 4500 475784278 CHVBK 20180406123653.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s004310051300 doi (NATIONALLICENCE)springer-10.1007/s004310051300 Serum vascular endothelial growth factor: a new predictive indicator for the occurrence of coronary artery lesions in Kawasaki disease [Elektronische Daten] [Takuro Ohno, Hisaji Igarashi, Kazuhiko Inoue, Kouhei Akazawa, Kunitaka Joh-o, Toshiro Hara] We investigated serum vascular endothelial growth factor (SVEGF) levels in Kawasaki disease and determined whether these levels had any association with the development of coronary artery lesions. We measured SVEGF levels in 66 patients with Kawasaki disease, 18 patients with active infections and 18 afebrile controls. SVEGF levels of patients in the acute phase of Kawasaki disease (0.0-2003.6 pg/ml, median 59.87 pg/ml) were significantly higher than those of patients with active infections (0.0-45.2 pg/ml, median 8.10 pg/ml; P < 0.05) or afebrile controls (0.0-49.8 pg/ml, median 7.75 pg/ml; P < 0.05) and decreased to undetectable or low levels in the recovery phase (n=31, acute phase: 0.0-2003.6 pg/ml, median 62.50 pg/ml versus recovery phase: 0.0-146.5 pg/ml, median 26.90 pg/ml; P=0.0007) of the disease. There existed a positive correlation between SVEGF levels and serum C-reactive protein concentrations in the acute phase of Kawasaki disease (r s =0.347, P=0.0051). In addition, SVEGF level and duration of fever were found to be major risk factors for the occurrence of coronary artery lesions by univariate (P=0.012 and P=0.003, respectively) and multivariate (P=0.037, OR 6.16 and P=0.0059, OR 7.59, respectively) analyses. Conclusion Serum vascular endothelial growth factor level, in combination with persistence of fever, could be a powerful predictor for the development of coronary aneurysms. Springer-Verlag Berlin Heidelberg, 2000 Key words Serum vascular endothelial growth factor nationallicence Coronary artery lesion nationallicence Kawasaki disease nationallicence AbbreviationsCAL coronary artery lesion nationallicence IVGG intravenous gammaglobulin nationallicence KD Kawasaki disease nationallicence Pc corrected p value nationallicence SVEGF serum vascular endothelial nationallicence growth factor nationallicence Ohno Takuro Department of Paediatrics, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashiku, Fukuoka 812-8582, Japan Tel.: +81-92-6425421; Fax: +88-92-6425435, JP aut Igarashi Hisaji Department of Paediatrics, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashiku, Fukuoka 812-8582, Japan Tel.: +81-92-6425421; Fax: +88-92-6425435, JP aut Inoue Kazuhiko Department of Paediatrics, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashiku, Fukuoka 812-8582, Japan Tel.: +81-92-6425421; Fax: +88-92-6425435, JP aut Akazawa Kouhei Department of Medical Informatics, Faculty of Medicine, Kyushu University, Fukuoka, Japan, JP aut Joh-o Kunitaka Department of Paediatrics, Kyushu Kouseinenkin Hospital, Fukuoka, Japan, JP aut Hara Toshiro Department of Paediatrics, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashiku, Fukuoka 812-8582, Japan Tel.: +81-92-6425421; Fax: +88-92-6425435, JP aut https://doi.org/10.1007/s004310051300 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004310051300 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ohno Takuro Department of Paediatrics, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashiku, Fukuoka 812-8582, Japan Tel.: +81-92-6425421; Fax: +88-92-6425435, JP aut NATIONALLICENCE 700 1- Igarashi Hisaji Department of Paediatrics, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashiku, Fukuoka 812-8582, Japan Tel.: +81-92-6425421; Fax: +88-92-6425435, JP aut NATIONALLICENCE 700 1- Inoue Kazuhiko Department of Paediatrics, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashiku, Fukuoka 812-8582, Japan Tel.: +81-92-6425421; Fax: +88-92-6425435, JP aut NATIONALLICENCE 700 1- Akazawa Kouhei Department of Medical Informatics, Faculty of Medicine, Kyushu University, Fukuoka, Japan, JP aut NATIONALLICENCE 700 1- Joh-o Kunitaka Department of Paediatrics, Kyushu Kouseinenkin Hospital, Fukuoka, Japan, JP aut NATIONALLICENCE 700 1- Hara Toshiro Department of Paediatrics, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashiku, Fukuoka 812-8582, Japan Tel.: +81-92-6425421; Fax: +88-92-6425435, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer