caa a22 4500 475784332 CHVBK 20180406123653.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s004310051309 doi (NATIONALLICENCE)springer-10.1007/s004310051309 Serum inhibin B in normal term-born male and female neonates during the first week of life [Elektronische Daten] [Jean De Schepper, Franciska Verlinde, Rita Cortvrindt, Michel Callewaert, Johan Smitz] Inhibin B, a gonadal peptide regulating follicle stimulating hormone (FSH) secretion in adults, has been found during gestation in amniotic fluid, but at birth only in term cord blood of male babies. Since no data are available on the evolution of serum inhibin B during the 1st week of life, we studied changes in inhibin B using a specific and sensitive immunoassay in male and female neonates during the 1st week of life in relation to FSH and to evaluate the possible effect of perinatal factors on inhibin B production. Inhibin B was measured by a specific monoclonal enzyme-linked immunosorbent assay. Inhibin B was detectable in cord blood of all eight longitudinally studied male newborns, correlated negatively with the ponderal index and increased significantly on day 5 (from 54.2 ± 18.5 to 100.4 ± 34.8 ng/l, P < 0.005). Cord blood inhibin B was detected in only 1 out of 13 screened female neonates. In 48 at term-born females in whom inhibin B was measured on the 5th day of life, only 20 cases had a detectable level (between 8 and 68.6 ng/l). Inhibin B concentrations in cord blood and on day 5 were independent of duration of pregnancy, type of delivery, Apgar score and FSH concentration. Conclusion A sexual difference in serum inhibin B is already present at the end of gestation and changes in inhibin B during the 1st week of life are independent of follicle stimulating hormone changes and perinatal factors in both sexes. Our data suggest that neonatal inhibin B could be used to study whether the newborn has functional testes, i.e. in babies with ambiguous genitalia and/or bilateral cryptorchidism. Springer-Verlag Berlin Heidelberg, 2000 Key words Neonatal screening nationallicence Gonadotropins nationallicence Gonads nationallicence AbbreviationFSH Follicle stimulating hormone nationallicence De Schepper Jean Academic Hospital VUB, Laarbeeklaan 101, 1090 Brussels, Belgium Tel.: +32-2-4776061; Fax: +32-24776074, BE aut Verlinde Franciska Academic Hospital VUB, Laarbeeklaan 101, 1090 Brussels, Belgium Tel.: +32-2-4776061; Fax: +32-24776074, BE aut Cortvrindt Rita Department of Reproductive Medicine, University Hospital and Medical School, Free University of Brussels, Brussels, Belgium, BE aut Callewaert Michel Department of Reproductive Medicine, University Hospital and Medical School, Free University of Brussels, Brussels, Belgium, BE aut Smitz Johan Department of Reproductive Medicine, University Hospital and Medical School, Free University of Brussels, Brussels, Belgium, BE aut https://doi.org/10.1007/s004310051309 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004310051309 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- De Schepper Jean Academic Hospital VUB, Laarbeeklaan 101, 1090 Brussels, Belgium Tel.: +32-2-4776061; Fax: +32-24776074, BE aut NATIONALLICENCE 700 1- Verlinde Franciska Academic Hospital VUB, Laarbeeklaan 101, 1090 Brussels, Belgium Tel.: +32-2-4776061; Fax: +32-24776074, BE aut NATIONALLICENCE 700 1- Cortvrindt Rita Department of Reproductive Medicine, University Hospital and Medical School, Free University of Brussels, Brussels, Belgium, BE aut NATIONALLICENCE 700 1- Callewaert Michel Department of Reproductive Medicine, University Hospital and Medical School, Free University of Brussels, Brussels, Belgium, BE aut NATIONALLICENCE 700 1- Smitz Johan Department of Reproductive Medicine, University Hospital and Medical School, Free University of Brussels, Brussels, Belgium, BE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer