caa a22 4500 475784359 CHVBK 20180406123653.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/s004310000532 doi (NATIONALLICENCE)springer-10.1007/s004310000532 Therapeutic drug monitoring of once daily gentamicin in serum and saliva of children [Elektronische Daten] [Matitiahu Berkovitch, Michael Goldman, Rela Silverman, Zehava Chen-Levi, Revital Greenberg, Ora Marcus, Eliezer Lahat] Gentamicin is widely used in paediatric medicine and therapeutic monitoring is mandatory due to the narrow margin of safety. Saliva sampling may be of potential interest, especially in children in whom blood sampling is often difficult. Experience with once daily intravenous administration of aminoglycosides has grown in recent years. Gentamicin levels were measured in serum and saliva of 55 children treated with the drug (5 mg/kg per day), administered intravenously in three different regimens: thrice (n=19), twice (n=18), and once daily (n=18). No correlation was found between serum gentamicin concentrations and saliva levels when the drug was administered twice or thrice daily, however, there was good correlation when the drug was administered once daily (r 2=0.96, P < 0.0001). Conclusion In children with uncomplicated infections treated with once daily gentamicin, trough concentrations of the drug can be monitored in saliva. Springer-Verlag Berlin Heidelberg, 2000 Key words Gentamicin nationallicence Once daily nationallicence Children nationallicence Saliva nationallicence Berkovitch Matitiahu Department of Paediatrics, Assaf Harofeh Medical Centre, Zerifin, 70300, Israel e-mail: mberkovitch@asaf.health.gov.il Tel.: +972-8-9779117; Fax: +972-8-9779156, IL aut Goldman Michael Department of Paediatrics, Assaf Harofeh Medical Centre, Zerifin, 70300, Israel e-mail: mberkovitch@asaf.health.gov.il Tel.: +972-8-9779117; Fax: +972-8-9779156, IL aut Silverman Rela Department of Paediatrics, Assaf Harofeh Medical Centre, Zerifin, 70300, Israel e-mail: mberkovitch@asaf.health.gov.il Tel.: +972-8-9779117; Fax: +972-8-9779156, IL aut Chen-Levi Zehava Department of Biochemistry, Assaf Harofeh Medical Centre, Zerifin, Sackler School of Medicine, Tel-Aviv University, Israel, IL aut Greenberg Revital Department of Paediatrics, Assaf Harofeh Medical Centre, Zerifin, 70300, Israel e-mail: mberkovitch@asaf.health.gov.il Tel.: +972-8-9779117; Fax: +972-8-9779156, IL aut Marcus Ora Department of Biochemistry, Assaf Harofeh Medical Centre, Zerifin, Sackler School of Medicine, Tel-Aviv University, Israel, IL aut Lahat Eliezer Department of Paediatrics, Assaf Harofeh Medical Centre, Zerifin, 70300, Israel e-mail: mberkovitch@asaf.health.gov.il Tel.: +972-8-9779117; Fax: +972-8-9779156, IL aut https://doi.org/10.1007/s004310000532 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004310000532 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Berkovitch Matitiahu Department of Paediatrics, Assaf Harofeh Medical Centre, Zerifin, 70300, Israel e-mail: mberkovitch@asaf.health.gov.il Tel.: +972-8-9779117; Fax: +972-8-9779156, IL aut NATIONALLICENCE 700 1- Goldman Michael Department of Paediatrics, Assaf Harofeh Medical Centre, Zerifin, 70300, Israel e-mail: mberkovitch@asaf.health.gov.il Tel.: +972-8-9779117; Fax: +972-8-9779156, IL aut NATIONALLICENCE 700 1- Silverman Rela Department of Paediatrics, Assaf Harofeh Medical Centre, Zerifin, 70300, Israel e-mail: mberkovitch@asaf.health.gov.il Tel.: +972-8-9779117; Fax: +972-8-9779156, IL aut NATIONALLICENCE 700 1- Chen-Levi Zehava Department of Biochemistry, Assaf Harofeh Medical Centre, Zerifin, Sackler School of Medicine, Tel-Aviv University, Israel, IL aut NATIONALLICENCE 700 1- Greenberg Revital Department of Paediatrics, Assaf Harofeh Medical Centre, Zerifin, 70300, Israel e-mail: mberkovitch@asaf.health.gov.il Tel.: +972-8-9779117; Fax: +972-8-9779156, IL aut NATIONALLICENCE 700 1- Marcus Ora Department of Biochemistry, Assaf Harofeh Medical Centre, Zerifin, Sackler School of Medicine, Tel-Aviv University, Israel, IL aut NATIONALLICENCE 700 1- Lahat Eliezer Department of Paediatrics, Assaf Harofeh Medical Centre, Zerifin, 70300, Israel e-mail: mberkovitch@asaf.health.gov.il Tel.: +972-8-9779117; Fax: +972-8-9779156, IL aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer