caa a22 4500 475784413 CHVBK 20180406123654.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/PL00008400 doi (NATIONALLICENCE)springer-10.1007/PL00008400 Current evidence for the use of paediatric antiretroviral therapy - a PENTA analysis [Elektronische Daten] [Michael Sharland, Diana Gibb, Carlo Giaquinto] The introduction of combination antiretroviral therapy has been associated with a dramatic clinical improvement in children with human immunodeficiency virus infection. However, the uptake of antiretroviral therapy has been variable across Europe. The Paediatric European Network for the Treatment of AIDS Steering Committee has performed a systematic literature review of paediatric antiretroviral therapy trials. An analysis of the evidence base for the commencement and maintenance of antiretroviral therapy was produced. Suggestions for when to commence antiretroviral therapy, which drugs to start with and how to monitor and sequence drug regimens are given. Conclusion The aim of these guidelines is to help in obtaining equity of access to a uniformly high standard of care for children with human immunodeficiency virus infection in all European countries. Springer-Verlag Berlin Heidelberg, 2000 Key words Antiretroviral therapy nationallicence Children nationallicence AIDS nationallicence Sharland Michael Paediatric Infectious Diseases Unit, St George's Hospital, Blackshaw Road, London SW17 0QT, UK e-mail m.sharland@sghms.ac.uk Fax: +44 208 7253262, GB aut Gibb Diana MRC Clinical Trials Unit, London, UK, GB aut Giaquinto Carlo University of Padua, Padua, Italy, IT aut https://doi.org/10.1007/PL00008400 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00008400 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sharland Michael Paediatric Infectious Diseases Unit, St George's Hospital, Blackshaw Road, London SW17 0QT, UK e-mail m.sharland@sghms.ac.uk Fax: +44 208 7253262, GB aut NATIONALLICENCE 700 1- Gibb Diana MRC Clinical Trials Unit, London, UK, GB aut NATIONALLICENCE 700 1- Giaquinto Carlo University of Padua, Padua, Italy, IT aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer