caa a22 4500 475784731 CHVBK 20180406123654.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1007/s004310051317 doi (NATIONALLICENCE)springer-10.1007/s004310051317 The geographic distribution of cystic fibrosis mutations gives clues about population origins [Elektronische Daten] [K. P. Dawson, P. M. Frossard] Information regarding three of the more common cystic fibrosis mutations is presented (ΔF508, G542X, N13031K) to support the concept of a geography associated with cystic fibrosis mutations. We present the hypothesis that a knowledge of the geography of cystic fibrosis mutations is important for an understanding of genotype-phenotype correlations, gene flow, historical population migration and cystic fibrosis screening. Conclusion A new method of study of mankind's cultural spread is being revealed and the survival of the various mutations supports the concept that they may provide a selective advantage to the carrier. Springer-Verlag Berlin Heidelberg, 2000 Key words Cystic fibrosis mutations nationallicence Geography nationallicence Population genetics nationallicence Dawson K. P. Department of Paediatrics, Faculty of Medicine and Health Sciences, UAE University, PO Box 17666, Al Ain, United Arab Emirates, AE aut Frossard P. M. Department of Pathology, Faculty of Medicine and Health Sciences, UAE University, PO Box 17666, Al Ain, United Arab Emirates, AE aut https://doi.org/10.1007/s004310051317 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004310051317 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dawson K. P. Department of Paediatrics, Faculty of Medicine and Health Sciences, UAE University, PO Box 17666, Al Ain, United Arab Emirates, AE aut NATIONALLICENCE 700 1- Frossard P. M. Department of Pathology, Faculty of Medicine and Health Sciences, UAE University, PO Box 17666, Al Ain, United Arab Emirates, AE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer