caa a22 4500 475784960 CHVBK 20180406123655.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1007/PL00008364 doi (NATIONALLICENCE)springer-10.1007/PL00008364 Near fatal acute colchicine intoxication in a child. A case report [Elektronische Daten] [Aviv Goldbart, Joseph Press, Shaul Sofer, Joseph Kapelushnik] An 8-year-old child with familial Mediterranean fever exhibited signs of colchicine intoxication while receiving prophylactic doses of the drug. She developed gastro-intestinal, central nervous system, cardiovascular and haematological disturbances. Over 2 months she had been drinking high doses of natural grapefruit juice which, combined with long-term colchicine therapy and a viral upper respiratory tract infection, increased her susceptibility to the drug. Conclusion To the best of our knowledge, this is the first time colchicine intoxication in this age group has been described in the English literature. Springer-Verlag Berlin Heidelberg, 2000 Key words Colchicine intoxication nationallicence Familial Mediterranean fever nationallicence Grapefruit juice nationallicence AbbreviationFMF familial Mediterranean fever nationallicence Goldbart Aviv Paediatric Department B, Soroka University Medical Centre, Ben-Gurion University of the Negev, Beer-Sheva, Israel, IL aut Press Joseph Paediatric Rheumatology Unit, Soroka University Medical Centre, Ben-Gurion University of the Negev, Beer-Sheva, Israel, IL aut Sofer Shaul Paediatric Intensive Care Unit, Soroka University Medical Centre, Ben-Gurion University of the Negev, Beer-Sheva, Israel, IL aut Kapelushnik Joseph Paediatric Haemato-Oncology Unit, Soroka University Medical Centre, Ben-Gurion University of the Negev, PO Box 151, Beer-Sheva, Israel e-mail: Kapelush@bgumail.bgu.ac.il Fax: +972-7-6400528, IL aut https://doi.org/10.1007/PL00008364 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00008364 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Goldbart Aviv Paediatric Department B, Soroka University Medical Centre, Ben-Gurion University of the Negev, Beer-Sheva, Israel, IL aut NATIONALLICENCE 700 1- Press Joseph Paediatric Rheumatology Unit, Soroka University Medical Centre, Ben-Gurion University of the Negev, Beer-Sheva, Israel, IL aut NATIONALLICENCE 700 1- Sofer Shaul Paediatric Intensive Care Unit, Soroka University Medical Centre, Ben-Gurion University of the Negev, Beer-Sheva, Israel, IL aut NATIONALLICENCE 700 1- Kapelushnik Joseph Paediatric Haemato-Oncology Unit, Soroka University Medical Centre, Ben-Gurion University of the Negev, PO Box 151, Beer-Sheva, Israel e-mail: Kapelush@bgumail.bgu.ac.il Fax: +972-7-6400528, IL aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer