caa a22 4500 475785096 CHVBK 20180406123655.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1007/PL00008365 doi (NATIONALLICENCE)springer-10.1007/PL00008365 Early infantile pertussis; increasingly prevalent and potentially fatal [Elektronische Daten] [Craig Smith, Harish Vyas] We report nine cases of severe early pertussis in infants less than 7 weeks of age. Clinical features at this age are atypical and may be confused with more common illnesses such as bronchiolitis. All were very difficult to manage. Ventilation was required for apnoeas in five cases, seizures in two or respiratory failure in two. Complications included hypotension in seven cases, pulmonary hypertension in one, pneumothoraces in two, seizures in five and co-infection in five. Two cases were referred for extracorporeal membrane oxygenation and six died. Infection was confirmed either at post mortem or by culture from pernasal swabs. The mother or other close family members were symptomatic at the time and thought to be the source of infection. Conclusion The nine cases suggest a significant resurgence of the infection, which may be fatal in early life. If reporting continues to increase, the immunisation schedule will need to be reviewed and secondary transmission prevented where possible, to protect this vulnerable pre-immunisation group. Springer-Verlag Berlin Heidelberg, 2000 Key words Immunisation nationallicence Infantile nationallicence Pertussis nationallicence Vaccination nationallicence AbbreviationsECMO extracorporeal membrane oxygenation nationallicence HFOV high frequency oscillatory ventilation nationallicence RSV respiratory syncytial virus nationallicence Smith Craig Paediatric Intensive Care Unit, University Hospital, Queens Medical Centre, Nottingham NG7 2UH, UK e-mail: harish.vyas@mail.qmcuh-tr.trent.nhs.uk Tel.: +44-115-9249924 extension 44841; Fax: 44-115-9420324, GB aut Vyas Harish Paediatric Intensive Care Unit, University Hospital, Queens Medical Centre, Nottingham NG7 2UH, UK e-mail: harish.vyas@mail.qmcuh-tr.trent.nhs.uk Tel.: +44-115-9249924 extension 44841; Fax: 44-115-9420324, GB aut https://doi.org/10.1007/PL00008365 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00008365 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Smith Craig Paediatric Intensive Care Unit, University Hospital, Queens Medical Centre, Nottingham NG7 2UH, UK e-mail: harish.vyas@mail.qmcuh-tr.trent.nhs.uk Tel.: +44-115-9249924 extension 44841; Fax: 44-115-9420324, GB aut NATIONALLICENCE 700 1- Vyas Harish Paediatric Intensive Care Unit, University Hospital, Queens Medical Centre, Nottingham NG7 2UH, UK e-mail: harish.vyas@mail.qmcuh-tr.trent.nhs.uk Tel.: +44-115-9249924 extension 44841; Fax: 44-115-9420324, GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer