caa a22 4500 475785169 CHVBK 20180406123656.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1007/s004310050039 doi (NATIONALLICENCE)springer-10.1007/s004310050039 Isolated cutaneous response to granulocyte-monocyte colony stimulating factor in fatal idiopathic disseminated Bacillus-Calmette-Guerin infection [Elektronische Daten] [O. Sanal, G. Morgan, A. Göçmen, V. Novelli, N. Klein, I. Tezcan, F. Ersoy, A. I. Berkel, L. Yel] Severe disseminated Bacillus-Calmette-Guerin (BCG) infection is very rare and has been regarded as idiopathic when no immunodeficiency is present. This entity seems to be due to several new types of inherited abnormalities in the pathways important in defence against Mycobacteria. Although improvement with interferon-γ (IFN-γ) has been reported in some patients, to our knowledge there are no reports on the effect of other cytokines in the treatment of these patients. We report here the clinical response to IFN-γ and granulocyte-monocyte colony stimulating factor (GM-CSF) treatment in a patient with idiopathic disseminated BCG infection who failed to respond to multiple antimycobacterial agents. The patient showed partial and transitory response to IFN-γ, however, GM-CSF treatment led to rapid improvement of skin lesions within 2 weeks without any effect on the progression of the disease in the other organ systems. Conclusion The response of idiopathic disseminated Bacillus-Calmette-Guerin infection to granulocyte-monocyte colony stimulating factor treatment was limited to cutaneous lesions. Granulocyte-monocyte colony stimulating factor may have acted to promote wound healing or the levels of this factor achieved in other affected organs may have been inadequate. Springer-Verlag Berlin Heidelberg, 2000 Key words Bacillus-Calmette Guerin nationallicence Disseminated infection nationallicence Granulocyte-monocyte colony stimulating factor nationallicence Interferon-γ nationallicence Sanal O. Immunology Division, Department of Paediatrics, Hacettepe University Children's Hospital, 06100, Ankara, Turkey e-mail: sanaloz@tr-net.net.tr Tel.: +90-312-3051172; Fax: +90-312-3241681, TR aut Morgan G. Department of Immunology and Infectious Disease, The Hospital for Sick Children, Great Ormond Street, London, UK, GB aut Göçmen A. Division of Chest Disease, Department of Paediatrics, Hacettepe University Medical School, Ankara, Turkey, TR aut Novelli V. Department of Immunology and Infectious Disease, The Hospital for Sick Children, Great Ormond Street, London, UK, GB aut Klein N. Department of Immunology and Infectious Disease, The Hospital for Sick Children, Great Ormond Street, London, UK, GB aut Tezcan I. Immunology Division, Department of Paediatrics, Hacettepe University Children's Hospital, 06100, Ankara, Turkey e-mail: sanaloz@tr-net.net.tr Tel.: +90-312-3051172; Fax: +90-312-3241681, TR aut Ersoy F. Immunology Division, Department of Paediatrics, Hacettepe University Children's Hospital, 06100, Ankara, Turkey e-mail: sanaloz@tr-net.net.tr Tel.: +90-312-3051172; Fax: +90-312-3241681, TR aut Berkel A. I. Immunology Division, Department of Paediatrics, Hacettepe University Children's Hospital, 06100, Ankara, Turkey e-mail: sanaloz@tr-net.net.tr Tel.: +90-312-3051172; Fax: +90-312-3241681, TR aut Yel L. Immunology Division, Department of Paediatrics, Hacettepe University Children's Hospital, 06100, Ankara, Turkey e-mail: sanaloz@tr-net.net.tr Tel.: +90-312-3051172; Fax: +90-312-3241681, TR aut https://doi.org/10.1007/s004310050039 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004310050039 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sanal O. Immunology Division, Department of Paediatrics, Hacettepe University Children's Hospital, 06100, Ankara, Turkey e-mail: sanaloz@tr-net.net.tr Tel.: +90-312-3051172; Fax: +90-312-3241681, TR aut NATIONALLICENCE 700 1- Morgan G. Department of Immunology and Infectious Disease, The Hospital for Sick Children, Great Ormond Street, London, UK, GB aut NATIONALLICENCE 700 1- Göçmen A. Division of Chest Disease, Department of Paediatrics, Hacettepe University Medical School, Ankara, Turkey, TR aut NATIONALLICENCE 700 1- Novelli V. Department of Immunology and Infectious Disease, The Hospital for Sick Children, Great Ormond Street, London, UK, GB aut NATIONALLICENCE 700 1- Klein N. Department of Immunology and Infectious Disease, The Hospital for Sick Children, Great Ormond Street, London, UK, GB aut NATIONALLICENCE 700 1- Tezcan I. Immunology Division, Department of Paediatrics, Hacettepe University Children's Hospital, 06100, Ankara, Turkey e-mail: sanaloz@tr-net.net.tr Tel.: +90-312-3051172; Fax: +90-312-3241681, TR aut NATIONALLICENCE 700 1- Ersoy F. Immunology Division, Department of Paediatrics, Hacettepe University Children's Hospital, 06100, Ankara, Turkey e-mail: sanaloz@tr-net.net.tr Tel.: +90-312-3051172; Fax: +90-312-3241681, TR aut NATIONALLICENCE 700 1- Berkel A. I. Immunology Division, Department of Paediatrics, Hacettepe University Children's Hospital, 06100, Ankara, Turkey e-mail: sanaloz@tr-net.net.tr Tel.: +90-312-3051172; Fax: +90-312-3241681, TR aut NATIONALLICENCE 700 1- Yel L. Immunology Division, Department of Paediatrics, Hacettepe University Children's Hospital, 06100, Ankara, Turkey e-mail: sanaloz@tr-net.net.tr Tel.: +90-312-3051172; Fax: +90-312-3241681, TR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer