caa a22 4500 475785266 CHVBK 20180406123656.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1007/s004310050041 doi (NATIONALLICENCE)springer-10.1007/s004310050041 Plasma concentrations of granulocyte-macrophage colony-stimulating factor and interleukin-6 in septic and healthy preterms [Elektronische Daten] [M. Kantar, N. Kültürsay, N. Kütükçüler, M. Akisü, N. Çetingül, S. Çaglayan] Plasma granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-6 (IL-6) concentrations were determined in 21 preterm infants with sepsis and nine healthy preterm neonates of the same postnatal age at sampling. Plasma GM-CSF levels were elevated at diagnosis in the septic preterms as compared to the healthy preterms (P = 0.01), but did not differ significantly on recovery. IL-6 levels were also elevated markedly at diagnosis (P = 0.0003), but decreased to normal on recovery as compared to the healthy preterm infants. GM-CSF levels were more prominent in septic preterms with neutropenia than those of non-neutropenic infants (P = 0.03). Conclusion Preterm infants can produce high levels of granulocyte-macrophage colony-stimulating factor and interleukin-6 in response to bacterial sepsis. Springer-Verlag Berlin Heidelberg, 2000 Key words Sepsis nationallicence Prematurity nationallicence Granulocyte-macrophage colony-stimulating factor nationallicence Interleukin-6 nationallicence Kantar M. Department of Paediatrics, Ege University Faculty of Medicine, 35100 Bornova, Izmir, Turkey e-mail: mkantar@med.ege.edu.tr Tel.: +90-232-3426990; Fax: +90-232-3426990, TR aut Kültürsay N. Department of Paediatrics, Ege University Faculty of Medicine, 35100 Bornova, Izmir, Turkey e-mail: mkantar@med.ege.edu.tr Tel.: +90-232-3426990; Fax: +90-232-3426990, TR aut Kütükçüler N. Department of Paediatrics, Ege University Faculty of Medicine, 35100 Bornova, Izmir, Turkey e-mail: mkantar@med.ege.edu.tr Tel.: +90-232-3426990; Fax: +90-232-3426990, TR aut Akisü M. Department of Paediatrics, Ege University Faculty of Medicine, 35100 Bornova, Izmir, Turkey e-mail: mkantar@med.ege.edu.tr Tel.: +90-232-3426990; Fax: +90-232-3426990, TR aut Çetingül N. Department of Paediatrics, Ege University Faculty of Medicine, 35100 Bornova, Izmir, Turkey e-mail: mkantar@med.ege.edu.tr Tel.: +90-232-3426990; Fax: +90-232-3426990, TR aut Çaglayan S. Department of Paediatrics, Ege University Faculty of Medicine, 35100 Bornova, Izmir, Turkey e-mail: mkantar@med.ege.edu.tr Tel.: +90-232-3426990; Fax: +90-232-3426990, TR aut https://doi.org/10.1007/s004310050041 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004310050041 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kantar M. Department of Paediatrics, Ege University Faculty of Medicine, 35100 Bornova, Izmir, Turkey e-mail: mkantar@med.ege.edu.tr Tel.: +90-232-3426990; Fax: +90-232-3426990, TR aut NATIONALLICENCE 700 1- Kültürsay N. Department of Paediatrics, Ege University Faculty of Medicine, 35100 Bornova, Izmir, Turkey e-mail: mkantar@med.ege.edu.tr Tel.: +90-232-3426990; Fax: +90-232-3426990, TR aut NATIONALLICENCE 700 1- Kütükçüler N. Department of Paediatrics, Ege University Faculty of Medicine, 35100 Bornova, Izmir, Turkey e-mail: mkantar@med.ege.edu.tr Tel.: +90-232-3426990; Fax: +90-232-3426990, TR aut NATIONALLICENCE 700 1- Akisü M. Department of Paediatrics, Ege University Faculty of Medicine, 35100 Bornova, Izmir, Turkey e-mail: mkantar@med.ege.edu.tr Tel.: +90-232-3426990; Fax: +90-232-3426990, TR aut NATIONALLICENCE 700 1- Çetingül N. Department of Paediatrics, Ege University Faculty of Medicine, 35100 Bornova, Izmir, Turkey e-mail: mkantar@med.ege.edu.tr Tel.: +90-232-3426990; Fax: +90-232-3426990, TR aut NATIONALLICENCE 700 1- Çaglayan S. Department of Paediatrics, Ege University Faculty of Medicine, 35100 Bornova, Izmir, Turkey e-mail: mkantar@med.ege.edu.tr Tel.: +90-232-3426990; Fax: +90-232-3426990, TR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer