caa a22 4500 475785347 CHVBK 20180406123656.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1007/s004310050053 doi (NATIONALLICENCE)springer-10.1007/s004310050053 Bone mineral density of the lumbar spine in very-low-birth-weight infants: a longitudinal study [Elektronische Daten] [H. Ichiba, H. Shintaku, M. Fujimaru, C. Hirai, Y. Okano, M. Funato] To examine osteopenia in very low birth weight (VLBW) infants we used repeated dual-energy X-ray absorptiometry in a prospective study of lumbar spinal bone mineral density (BMD) in Japanese VLBW infants (birthweight 426-1498 g; n = 61, group 1) aged 40 weeks postconception to 3 years of age. Control subjects were Japanese infants with birthweight 1500-1999 g (group 2), 2000-2499 g (group 3), or more than 2500 g (group 4). BMD in group 1 during the early period after birth was very low, increased rapidly for 1 year, and then gradually increased until 3 years of age (r =  0.931, P < 0.0001). BMD at the age of 40 weeks postconception was 0.085 ± 0.026, 0.132 ± 0.039, 0.178 ± 0.042, and 0.196 ± 0.046 g/cm2 in groups 1, 2, 3, and 4, respectively (P < 0.0001). However, at 1 and 2 years of age no differences were observed among the groups in BMD. Conclusion This study shows that lumbar spinal BMD in VLBW infants can normalize by the age of 2 years. Springer-Verlag Berlin Heidelberg, 2000 Key words Very-low-birth-weight infant nationallicence Bone mineral density nationallicence Dual energy X-ray absorptiometry nationallicence Osteopenia nationallicence Ichiba H. Department of Pediatrics, Osaka City University Medical School, 1-4-3 Asahimachi, Abenoku, Osaka 545-8586, Japan Tel.: +81-6-66453816; Fax: +81-6-66368737, JP aut Shintaku H. Department of Pediatrics, Osaka City University Medical School, 1-4-3 Asahimachi, Abenoku, Osaka 545-8586, Japan Tel.: +81-6-66453816; Fax: +81-6-66368737, JP aut Fujimaru M. Department of Pediatrics, Osaka City University Medical School, 1-4-3 Asahimachi, Abenoku, Osaka 545-8586, Japan Tel.: +81-6-66453816; Fax: +81-6-66368737, JP aut Hirai C. Department of Pediatrics, Osaka City University Medical School, 1-4-3 Asahimachi, Abenoku, Osaka 545-8586, Japan Tel.: +81-6-66453816; Fax: +81-6-66368737, JP aut Okano Y. Department of Pediatrics, Osaka City University Medical School, 1-4-3 Asahimachi, Abenoku, Osaka 545-8586, Japan Tel.: +81-6-66453816; Fax: +81-6-66368737, JP aut Funato M. Department of Pediatrics, Yodogawa Christian Hospital, Osaka, Japan, JP aut https://doi.org/10.1007/s004310050053 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004310050053 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ichiba H. Department of Pediatrics, Osaka City University Medical School, 1-4-3 Asahimachi, Abenoku, Osaka 545-8586, Japan Tel.: +81-6-66453816; Fax: +81-6-66368737, JP aut NATIONALLICENCE 700 1- Shintaku H. Department of Pediatrics, Osaka City University Medical School, 1-4-3 Asahimachi, Abenoku, Osaka 545-8586, Japan Tel.: +81-6-66453816; Fax: +81-6-66368737, JP aut NATIONALLICENCE 700 1- Fujimaru M. Department of Pediatrics, Osaka City University Medical School, 1-4-3 Asahimachi, Abenoku, Osaka 545-8586, Japan Tel.: +81-6-66453816; Fax: +81-6-66368737, JP aut NATIONALLICENCE 700 1- Hirai C. Department of Pediatrics, Osaka City University Medical School, 1-4-3 Asahimachi, Abenoku, Osaka 545-8586, Japan Tel.: +81-6-66453816; Fax: +81-6-66368737, JP aut NATIONALLICENCE 700 1- Okano Y. Department of Pediatrics, Osaka City University Medical School, 1-4-3 Asahimachi, Abenoku, Osaka 545-8586, Japan Tel.: +81-6-66453816; Fax: +81-6-66368737, JP aut NATIONALLICENCE 700 1- Funato M. Department of Pediatrics, Yodogawa Christian Hospital, Osaka, Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer