caa a22 4500 475785363 CHVBK 20180406123656.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/PL00008340 doi (NATIONALLICENCE)springer-10.1007/PL00008340 Prospective evaluation of late effects after childhood cancer therapy with a follow-up over 9 years [Elektronische Daten] [Herwig Lackner, Martin Benesch, Sabine Schagerl, Reinhold Kerbl, Wolfgang Schwinger, Christian Urban] Intensive multimodality treatment has led to a remarkable improvement of prognosis in paediatric cancer patients, however, a great number of long-term survivors suffer from considerable tumour- or treatment-related late effects. Between January 1990 and December 1998, 223 consecutive survivors of childhood malignancies entered a prospective follow-up study designed to evaluate the frequency and severity of tumour- and/or therapy-related long-term sequelae. After cessation of therapy and subsequently once a year, all patients underwent a detailed examination programme including physical examination, laboratory tests, abdominal sonography, echocardiography, electrocardiography, electroencephalography, spirometry, audiometry, ophthalmological examination and endocrine stimulation tests. Median follow-up was 5 years (range 0.4 to 9.6 years). A total of 167 patients (75%) had at least one chronic medical problem of whom 80 needed permanent medical support. The organ systems most frequently affected were the nervous system in 39%, the endocrine system in 32%, the ears/eyes in 22%, the kidneys in 17%, and the liver in 12% of the patients. Some late effects (endocrine deficits, hearing loss, tubulopathy) were primarily diagnosed only several years after the end of oncological therapy. Conclusion The results of this study indicate that a considerable number of former paediatric cancer patients suffer from remarkable long-term side-effects. Since life quality is an important parameter of cancer survival, careful follow-up of long-term survivors is mandatory with the aim to reduce or even abrogate possible side-effects at the earliest time. Springer-Verlag Berlin Heidelberg, 2000 Key words Long-term late effects nationallicence Childhood nationallicence Cancer nationallicence Therapy nationallicence Follow-up examinations nationallicence Lackner Herwig Division of Paediatric Haematology and Oncology, Department of Paediatrics, University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria e-mail: herwig.lackner@kfunigraz.ac.at Tel.: +43-316-3853485; Fax: +43-316-3853450, AT aut Benesch Martin Division of Paediatric Haematology and Oncology, Department of Paediatrics, University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria e-mail: herwig.lackner@kfunigraz.ac.at Tel.: +43-316-3853485; Fax: +43-316-3853450, AT aut Schagerl Sabine Division of Paediatric Haematology and Oncology, Department of Paediatrics, University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria e-mail: herwig.lackner@kfunigraz.ac.at Tel.: +43-316-3853485; Fax: +43-316-3853450, AT aut Kerbl Reinhold Division of Paediatric Haematology and Oncology, Department of Paediatrics, University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria e-mail: herwig.lackner@kfunigraz.ac.at Tel.: +43-316-3853485; Fax: +43-316-3853450, AT aut Schwinger Wolfgang Division of Paediatric Haematology and Oncology, Department of Paediatrics, University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria e-mail: herwig.lackner@kfunigraz.ac.at Tel.: +43-316-3853485; Fax: +43-316-3853450, AT aut Urban Christian Division of Paediatric Haematology and Oncology, Department of Paediatrics, University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria e-mail: herwig.lackner@kfunigraz.ac.at Tel.: +43-316-3853485; Fax: +43-316-3853450, AT aut https://doi.org/10.1007/PL00008340 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00008340 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lackner Herwig Division of Paediatric Haematology and Oncology, Department of Paediatrics, University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria e-mail: herwig.lackner@kfunigraz.ac.at Tel.: +43-316-3853485; Fax: +43-316-3853450, AT aut NATIONALLICENCE 700 1- Benesch Martin Division of Paediatric Haematology and Oncology, Department of Paediatrics, University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria e-mail: herwig.lackner@kfunigraz.ac.at Tel.: +43-316-3853485; Fax: +43-316-3853450, AT aut NATIONALLICENCE 700 1- Schagerl Sabine Division of Paediatric Haematology and Oncology, Department of Paediatrics, University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria e-mail: herwig.lackner@kfunigraz.ac.at Tel.: +43-316-3853485; Fax: +43-316-3853450, AT aut NATIONALLICENCE 700 1- Kerbl Reinhold Division of Paediatric Haematology and Oncology, Department of Paediatrics, University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria e-mail: herwig.lackner@kfunigraz.ac.at Tel.: +43-316-3853485; Fax: +43-316-3853450, AT aut NATIONALLICENCE 700 1- Schwinger Wolfgang Division of Paediatric Haematology and Oncology, Department of Paediatrics, University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria e-mail: herwig.lackner@kfunigraz.ac.at Tel.: +43-316-3853485; Fax: +43-316-3853450, AT aut NATIONALLICENCE 700 1- Urban Christian Division of Paediatric Haematology and Oncology, Department of Paediatrics, University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria e-mail: herwig.lackner@kfunigraz.ac.at Tel.: +43-316-3853485; Fax: +43-316-3853450, AT aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer