caa a22 4500 475785371 CHVBK 20180406123656.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/s004310000544 doi (NATIONALLICENCE)springer-10.1007/s004310000544 Gastro-oesophageal reflux, sleep pattern, apparent life threatening event and sudden infant death. The point of view of a gastro-enterologist [Elektronische Daten] [Yvan Vandenplas, Bruno Hauser] Sudden infant death, apparent life threatening events and regurgitation occur mostly during the first 6 months of life, making it very tempting to suspect a relation between these phenomena. According to epidemiological data, the role of gastro-oesophageal reflux in the aetiology of apparent life threatening events is unclear. It has been demonstrated that sudden infant death is decreased in the supine versus the prone sleeping position. On the contrary, gastro-oesophageal reflux is more pronounced in the supine than in the prone position, both in infants and in older children, both in infants with physiological and with pathological reflux. In the supine position, infants do sleep shorter, have more rapid-eye-movement sleep and have more arousals than in the prone position. Conclusion It is thought that in the majority of infants, gastro-oesophageal reflux stimulates arousals and thus may well be considered as "protective” for rather than "provoking” sudden infant death. However, this hypothesis needs to be validated. Springer-Verlag Berlin Heidelberg, 2000 Key words Apnoea nationallicence Apparent life threatening event nationallicence Gastro-oesophageal reflux nationallicence Regurgitation nationallicence Sudden infant death nationallicence Vandenplas Yvan AZ-VUB, Laarbeeklaan 101, 1090 Brussels, Belgium e-mail: pedvsy@az.vub.ac.be Tel.: +32-2-4775780; Fax: +32-2-4775783, BE aut Hauser Bruno AZ-VUB, Laarbeeklaan 101, 1090 Brussels, Belgium e-mail: pedvsy@az.vub.ac.be Tel.: +32-2-4775780; Fax: +32-2-4775783, BE aut https://doi.org/10.1007/s004310000544 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004310000544 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vandenplas Yvan AZ-VUB, Laarbeeklaan 101, 1090 Brussels, Belgium e-mail: pedvsy@az.vub.ac.be Tel.: +32-2-4775780; Fax: +32-2-4775783, BE aut NATIONALLICENCE 700 1- Hauser Bruno AZ-VUB, Laarbeeklaan 101, 1090 Brussels, Belgium e-mail: pedvsy@az.vub.ac.be Tel.: +32-2-4775780; Fax: +32-2-4775783, BE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer