caa a22 4500 47578538X CHVBK 20180406123656.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/PL00008346 doi (NATIONALLICENCE)springer-10.1007/PL00008346 Effectiveness of antiretroviral therapy initiated before the age of 2 months in infants vertically infected with human immunodeficiency virus type 1 [Elektronische Daten] [Marc Hainaut, Cécile Alexandra Peltier, Michèle Gérard, Denise Marissens, Georges Zissis, Jack Levy] The effectiveness and tolerance of antiretroviral therapy with a combination of three reverse transcriptase inhibitors starting at the time of diagnosis (before 2 months of age) was evaluated in four infants with vertically acquired HIV-1 infection. Plasma HIV-1 RNA levels ranged from 230,000 to 1,000,000 copies/ml before onset of triple therapy and fell below 50 copies/ml at 12 to 33 weeks of life in three of the infants. These three children, currently aged 158, 105 and 72 weeks, are asymptomatic, have normal lymphocyte subsets and no hypergammaglobulinaemia. Two children experienced a profound reduction in the amount of proviral DNA detected in blood and have become HIV-1 seronegative, although one of them has had HIV-1 RNA detectable on a single occasion at 114 weeks of life (303 copies/ml). Transient interruption of therapy resulted in a rapid but reversible increase in HIV-1 RNA levels in the third child and was associated with the production of HIV-specific antibodies. The fourth child whose parents were not compliant to treatment and follow-up had a poor virological response. Conclusion Early treatment of vertically acquired human immunodeficiency virus type 1 infection with three reverse transcriptase inhibitors is well tolerated and can result in such suppression of viral replication that specific antibodies are not produced, that proviral DNA falls to the lower limit of quantitation in blood and that all clinical and immunological manifestations of infection are avoided. Parental adhesion is crucial to the effectiveness of therapy. Springer-Verlag Berlin Heidelberg, 2000 Key words Paediatrics nationallicence Antiretroviral therapy nationallicence HIV-1 infection nationallicence Reverse transcriptase inhibitors nationallicence Hainaut Marc Department of Paediatrics, CHU Saint-Pierre, 322 rue Haute, 1000 Bruxelles, Belgium Tel.: +32-2-5354344; Fax: +32-2-5354563, BE aut Peltier Cécile Alexandra Department of Paediatrics, CHU Saint-Pierre, 322 rue Haute, 1000 Bruxelles, Belgium Tel.: +32-2-5354344; Fax: +32-2-5354563, BE aut Gérard Michèle Department of Internal Medicine, CHU Saint-Pierre, Bruxelles, Belgium, BE aut Marissens Denise AIDS Reference Laboratory, VUB, CHU Saint-Pierre, Bruxelles, Belgium, BE aut Zissis Georges AIDS Reference Laboratory, VUB, CHU Saint-Pierre, Bruxelles, Belgium, BE aut Levy Jack Department of Paediatrics, CHU Saint-Pierre, 322 rue Haute, 1000 Bruxelles, Belgium Tel.: +32-2-5354344; Fax: +32-2-5354563, BE aut https://doi.org/10.1007/PL00008346 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00008346 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hainaut Marc Department of Paediatrics, CHU Saint-Pierre, 322 rue Haute, 1000 Bruxelles, Belgium Tel.: +32-2-5354344; Fax: +32-2-5354563, BE aut NATIONALLICENCE 700 1- Peltier Cécile Alexandra Department of Paediatrics, CHU Saint-Pierre, 322 rue Haute, 1000 Bruxelles, Belgium Tel.: +32-2-5354344; Fax: +32-2-5354563, BE aut NATIONALLICENCE 700 1- Gérard Michèle Department of Internal Medicine, CHU Saint-Pierre, Bruxelles, Belgium, BE aut NATIONALLICENCE 700 1- Marissens Denise AIDS Reference Laboratory, VUB, CHU Saint-Pierre, Bruxelles, Belgium, BE aut NATIONALLICENCE 700 1- Zissis Georges AIDS Reference Laboratory, VUB, CHU Saint-Pierre, Bruxelles, Belgium, BE aut NATIONALLICENCE 700 1- Levy Jack Department of Paediatrics, CHU Saint-Pierre, 322 rue Haute, 1000 Bruxelles, Belgium Tel.: +32-2-5354344; Fax: +32-2-5354563, BE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer