caa a22 4500 475785444 CHVBK 20180406123656.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/PL00008345 doi (NATIONALLICENCE)springer-10.1007/PL00008345 A randomised controlled trial of delayed cord clamping in very low birth weight preterm infants [Elektronische Daten] [Heike Rabe, Anne Wacker, Georg Hülskamp, Isabell Hörnig-Franz, Anne Schulze-Everding, Erik Harms, Ulrich Cirkel, Frank Louwen, Ralf Witteler, Hermann P. G. Schneider] This study was carried out to assess the feasibility of late cord clamping of 45 s in preterm infants delivered mainly by caesarean section and the effects on post-partal adaptation and anaemia of prematurity. Prior to delivery, 40 infants of <33 gestational weeks were randomised to either 20 s or 45 s of late cord clamping. After the first shoulder was delivered, oxytocin was given intravenously to the mother in order to enhance placento-fetal transfusion while the infant was held below the level of the placenta. The 20 infants in group 1 (20 s) had a mean birth weight of 1070 g and a mean gestational age of 29 + 4/7 weeks versus 1190 g and 30 weeks in group 2 (45 s). On day 42 of life there were ten infants without transfusions in group 2 versus three in group 1 (P < 0.05). Out of the 20 infants in group 1, 19 and 15/19 in group 2 were delivered by caesarean section. There were no significant differences in Apgar scores, temperature on admission, heart rate, blood pressure and requirements for artificial ventilation. Conclusion Delayed cord clamping of 45 s is feasible and safe in preterm infants below 33 weeks of gestation. It is possible to perform the procedure at caesarean section deliveries and it should be performed whenever possible. It reduces the need for packed red cell transfusions during the first 6 weeks of life. Springer-Verlag Berlin Heidelberg, 2000 Key words Delayed cord clamping nationallicence Preterm infants nationallicence Rabe Heike Department of Paediatrics, University Children's Hospital, Albert-Schweitzer-Str. 33, 48129 Münster, Germany e-mail: hrabe@uni-muenster.de Tel.: +49-251-8347810; Fax: +49-251-8347809, DE aut Wacker Anne Department of Paediatrics, University Children's Hospital, Albert-Schweitzer-Str. 33, 48129 Münster, Germany e-mail: hrabe@uni-muenster.de Tel.: +49-251-8347810; Fax: +49-251-8347809, DE aut Hülskamp Georg Department of Paediatrics, University Children's Hospital, Albert-Schweitzer-Str. 33, 48129 Münster, Germany e-mail: hrabe@uni-muenster.de Tel.: +49-251-8347810; Fax: +49-251-8347809, DE aut Hörnig-Franz Isabell Department of Paediatrics, University Children's Hospital, Albert-Schweitzer-Str. 33, 48129 Münster, Germany e-mail: hrabe@uni-muenster.de Tel.: +49-251-8347810; Fax: +49-251-8347809, DE aut Schulze-Everding Anne Department of Paediatrics, University Children's Hospital, Albert-Schweitzer-Str. 33, 48129 Münster, Germany e-mail: hrabe@uni-muenster.de Tel.: +49-251-8347810; Fax: +49-251-8347809, DE aut Harms Erik Department of Paediatrics, University Children's Hospital, Albert-Schweitzer-Str. 33, 48129 Münster, Germany e-mail: hrabe@uni-muenster.de Tel.: +49-251-8347810; Fax: +49-251-8347809, DE aut Cirkel Ulrich Department of Obstetrics and Gynaecology, University Hospital of Münster, Münster, Germany, DE aut Louwen Frank Department of Obstetrics and Gynaecology, University Hospital of Münster, Münster, Germany, DE aut Witteler Ralf Department of Obstetrics and Gynaecology, University Hospital of Münster, Münster, Germany, DE aut Schneider Hermann P. G. Department of Obstetrics and Gynaecology, University Hospital of Münster, Münster, Germany, DE aut https://doi.org/10.1007/PL00008345 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00008345 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rabe Heike Department of Paediatrics, University Children's Hospital, Albert-Schweitzer-Str. 33, 48129 Münster, Germany e-mail: hrabe@uni-muenster.de Tel.: +49-251-8347810; Fax: +49-251-8347809, DE aut NATIONALLICENCE 700 1- Wacker Anne Department of Paediatrics, University Children's Hospital, Albert-Schweitzer-Str. 33, 48129 Münster, Germany e-mail: hrabe@uni-muenster.de Tel.: +49-251-8347810; Fax: +49-251-8347809, DE aut NATIONALLICENCE 700 1- Hülskamp Georg Department of Paediatrics, University Children's Hospital, Albert-Schweitzer-Str. 33, 48129 Münster, Germany e-mail: hrabe@uni-muenster.de Tel.: +49-251-8347810; Fax: +49-251-8347809, DE aut NATIONALLICENCE 700 1- Hörnig-Franz Isabell Department of Paediatrics, University Children's Hospital, Albert-Schweitzer-Str. 33, 48129 Münster, Germany e-mail: hrabe@uni-muenster.de Tel.: +49-251-8347810; Fax: +49-251-8347809, DE aut NATIONALLICENCE 700 1- Schulze-Everding Anne Department of Paediatrics, University Children's Hospital, Albert-Schweitzer-Str. 33, 48129 Münster, Germany e-mail: hrabe@uni-muenster.de Tel.: +49-251-8347810; Fax: +49-251-8347809, DE aut NATIONALLICENCE 700 1- Harms Erik Department of Paediatrics, University Children's Hospital, Albert-Schweitzer-Str. 33, 48129 Münster, Germany e-mail: hrabe@uni-muenster.de Tel.: +49-251-8347810; Fax: +49-251-8347809, DE aut NATIONALLICENCE 700 1- Cirkel Ulrich Department of Obstetrics and Gynaecology, University Hospital of Münster, Münster, Germany, DE aut NATIONALLICENCE 700 1- Louwen Frank Department of Obstetrics and Gynaecology, University Hospital of Münster, Münster, Germany, DE aut NATIONALLICENCE 700 1- Witteler Ralf Department of Obstetrics and Gynaecology, University Hospital of Münster, Münster, Germany, DE aut NATIONALLICENCE 700 1- Schneider Hermann P. G. Department of Obstetrics and Gynaecology, University Hospital of Münster, Münster, Germany, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer