caa a22 4500 475785479 CHVBK 20180406123656.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/PL00008343 doi (NATIONALLICENCE)springer-10.1007/PL00008343 The effects of synthetic and natural surfactant on fluid balance in acute respiratory distress syndrome [Elektronische Daten] [Edile Murdoch, Stephen T. Kempley] To evaluate the effect of different surfactants on fluid balance in respiratory distress syndrome, we studied 24 premature infants who were randomised to receive either natural or synthetic surfactant. Data were collected on ventilatory parameters, daily urine output, daily weight, fluid intake and serum electrolytes. Ventilatory requirements decreased more rapidly in babies receiving natural surfactant, with significantly greater reductions in mean airway pressure from 1 to 48 h and oxygenation index from 1-18 h (P < 0.05). There were no differences in fluid intake and serum electrolytes. Mean daily urine output was higher in the group receiving natural surfactant (87 ml versus 61 ml, P < 0.05). This group also had a greater weight loss from birth weight (−146 g versus −65 g, P < 0.05). Conclusion Natural surfactant produces an earlier reduction in ventilatory requirements with an earlier diuresis. This should influence fluid management in respiratory distress syndrome. Springer-Verlag Berlin Heidelberg, 2000 Key words Surfactant nationallicence Fluid balance nationallicence Diuresis nationallicence Murdoch Edile Elizabeth Ward, Garden House Children's Unit, The Royal London Hospital, Whitechapel, London E1 1BB, UK Tel.: +44-207-3777712; Fax: +44-207-3777712, GB aut Kempley Stephen T. Elizabeth Ward, Garden House Children's Unit, The Royal London Hospital, Whitechapel, London E1 1BB, UK Tel.: +44-207-3777712; Fax: +44-207-3777712, GB aut https://doi.org/10.1007/PL00008343 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00008343 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Murdoch Edile Elizabeth Ward, Garden House Children's Unit, The Royal London Hospital, Whitechapel, London E1 1BB, UK Tel.: +44-207-3777712; Fax: +44-207-3777712, GB aut NATIONALLICENCE 700 1- Kempley Stephen T. Elizabeth Ward, Garden House Children's Unit, The Royal London Hospital, Whitechapel, London E1 1BB, UK Tel.: +44-207-3777712; Fax: +44-207-3777712, GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer