caa a22 4500 475785533 CHVBK 20180406123657.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/PL00008342 doi (NATIONALLICENCE)springer-10.1007/PL00008342 Improved dysgammaglobulinaemia in congenital rubella syndrome after immunoglobulin therapy: correlation with CD154 expression [Elektronische Daten] [Nobuaki Kawamura, Akiko Okamura, Hirofumi Furuta, Shigetaka Katow, Masafumi Yamada, Ichiro Kobayashi, Motohiko Okano, Kunihiko Kobayashi, Yukio Sakiyama] A boy with congenital rubella syndrome developed dysgammaglobulinaemia with elevated serum levels of IgM. CD154 was not induced on his peripheral blood mononuclear cells when rubella virus RNA was detected in his throat swabs and peripheral blood by reverse transcriptase polymerase chain reaction. Following intravenous immunoglobulin therapy, improvement of immunoglobulin abnormalities, disappearance of rubella virus and normalisation of CD154 expression were demonstrated. Conclusion These findings implicate the efficacy of intravenous immunoglobulin therapy for dysgammaglobulinaemia in congenital rubella syndrome and a role of CD154 for a prolonged virus infection. Springer-Verlag Berlin Heidelberg, 2000 Key words Congenital rubella syndrome nationallicence Dysgammaglobulinaemia nationallicence CD154 nationallicence Intravenous immunoglobulin therapy nationallicence Kawamura Nobuaki Department of Paediatrics, Hokkaido University School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan e-mail: nobu-ka@med.hokudai.ac.jp Tel.: +81-11-7161161 ext. 5954; Fax: +81-11-7067898, JP aut Okamura Akiko Department of Paediatrics, Hokkaido University School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan e-mail: nobu-ka@med.hokudai.ac.jp Tel.: +81-11-7161161 ext. 5954; Fax: +81-11-7067898, JP aut Furuta Hirofumi Department of Paediatrics, Hokkaido University School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan e-mail: nobu-ka@med.hokudai.ac.jp Tel.: +81-11-7161161 ext. 5954; Fax: +81-11-7067898, JP aut Katow Shigetaka Department of Viral Disease and Vaccine Control, National Institute of Infectious Diseases, Musashi-Murayama, Tokyo, Japan, JP aut Yamada Masafumi Department of Paediatrics, Hokkaido University School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan e-mail: nobu-ka@med.hokudai.ac.jp Tel.: +81-11-7161161 ext. 5954; Fax: +81-11-7067898, JP aut Kobayashi Ichiro Department of Paediatrics, Hokkaido University School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan e-mail: nobu-ka@med.hokudai.ac.jp Tel.: +81-11-7161161 ext. 5954; Fax: +81-11-7067898, JP aut Okano Motohiko Department of Paediatrics, Hokkaido University School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan e-mail: nobu-ka@med.hokudai.ac.jp Tel.: +81-11-7161161 ext. 5954; Fax: +81-11-7067898, JP aut Kobayashi Kunihiko Department of Paediatrics, Hokkaido University School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan e-mail: nobu-ka@med.hokudai.ac.jp Tel.: +81-11-7161161 ext. 5954; Fax: +81-11-7067898, JP aut Sakiyama Yukio Department of Human Gene Therapy, Hokkaido University School of Medicine, Sapporo, Japan, JP aut https://doi.org/10.1007/PL00008342 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00008342 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kawamura Nobuaki Department of Paediatrics, Hokkaido University School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan e-mail: nobu-ka@med.hokudai.ac.jp Tel.: +81-11-7161161 ext. 5954; Fax: +81-11-7067898, JP aut NATIONALLICENCE 700 1- Okamura Akiko Department of Paediatrics, Hokkaido University School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan e-mail: nobu-ka@med.hokudai.ac.jp Tel.: +81-11-7161161 ext. 5954; Fax: +81-11-7067898, JP aut NATIONALLICENCE 700 1- Furuta Hirofumi Department of Paediatrics, Hokkaido University School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan e-mail: nobu-ka@med.hokudai.ac.jp Tel.: +81-11-7161161 ext. 5954; Fax: +81-11-7067898, JP aut NATIONALLICENCE 700 1- Katow Shigetaka Department of Viral Disease and Vaccine Control, National Institute of Infectious Diseases, Musashi-Murayama, Tokyo, Japan, JP aut NATIONALLICENCE 700 1- Yamada Masafumi Department of Paediatrics, Hokkaido University School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan e-mail: nobu-ka@med.hokudai.ac.jp Tel.: +81-11-7161161 ext. 5954; Fax: +81-11-7067898, JP aut NATIONALLICENCE 700 1- Kobayashi Ichiro Department of Paediatrics, Hokkaido University School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan e-mail: nobu-ka@med.hokudai.ac.jp Tel.: +81-11-7161161 ext. 5954; Fax: +81-11-7067898, JP aut NATIONALLICENCE 700 1- Okano Motohiko Department of Paediatrics, Hokkaido University School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan e-mail: nobu-ka@med.hokudai.ac.jp Tel.: +81-11-7161161 ext. 5954; Fax: +81-11-7067898, JP aut NATIONALLICENCE 700 1- Kobayashi Kunihiko Department of Paediatrics, Hokkaido University School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan e-mail: nobu-ka@med.hokudai.ac.jp Tel.: +81-11-7161161 ext. 5954; Fax: +81-11-7067898, JP aut NATIONALLICENCE 700 1- Sakiyama Yukio Department of Human Gene Therapy, Hokkaido University School of Medicine, Sapporo, Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer